2021

Bettaieb L, Brulé M, Chomy A, Diedro M, Fruit M, Happernegg E, Heni L, Horochowska A, Housseini M, Klouyovo K, Laratte A, Leroy A, Lewandowski P, Louvieaux J, Moitié A, Tellier R, Titah S, Vanauberg D, Woesteland F, Prevarskaya N, Lehen'kyi V. Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma. Cancers (Basel). 2021 Jun 21;13(12):3085. doi: 10.3390/cancers13123085. PMID: 34205590; PMCID: PMC8235326 PubMed

Dubois C, Kondratska K, Kondratskyi A, Morabito A, Mesilmany L, Farfariello V, Toillon RA, Ziental Gelus N, Laurenge E, Vanden Abeele F, Lemonnier L, Prevarskaya N. ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma. Biochim Biophys Acta Mol Cell Res. 2021 Jun;1868(7):119023. doi: 10.1016/j.bbamcr.2021.119023. Epub 2021 Mar 30. PMID: 33798603 PubMed

Radoslavova S, Folcher A, Lefebvre T, Kondratska K, Guénin S, Dhennin-Duthille I, Gautier M, Prevarskaya N, Ouadid-Ahidouch H. Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGFβ1 Secretion through the AKT Signaling Pathway. Cancers (Basel). 2021 May 15;13(10):2395. doi: 10.3390/cancers13102395. PMID: 34063470; PMCID: PMC8156432 PubMed

Mesquita G, Prevarskaya N, Schwab A, Lehen'kyi V. Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression. Cells. 2021 Apr 26;10(5):1021. doi: 10.3390/cells10051021. PMID: 33925979; PMCID: PMC8145744 PubMed

Ziegler DV, Vindrieux D, Goehrig D, Jaber S, Collin G, Griveau A, Wiel C, Bendridi N, Djebali S, Farfariello V, Prevarskaya N, Payen L, Marvel J, Aubert S, Flaman JM, Rieusset J, Martin N, Bernard D. Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging. Nat Commun. 2021 Feb 1;12(1):720. doi: 10.1038/s41467-021-20993-z. PMID: 33526781; PMCID: PMC7851384 PubMed

Shapovalov G, Gordienko D, Prevarskaya N. Store operated calcium channels in cancer progression. Int Rev Cell Mol Biol. 2021;363:123-168. doi: 10.1016/bs.ircmb.2021.02.016. Epub 2021 Mar 30. PMID: 34392928 PubMed

 

2020

Farfariello V, Prevarskaya N, Gkika D. Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening. Rev Physiol Biochem Pharmacol. 2020 Aug 1. doi: 10.1007/112_2020_22. Epub ahead of print. PMID: 32737754 PubMed

Dubois C, Kondratskyi A, Bidaux G, Noyer L, Vancauwenberghe E, Farfariello V, Toillon RA, Roudbaraki M, Tierny D, Bonnal JL, Prevarskaya N, Vanden Abeele F. Co-targeting Mitochondrial Ca<sup>2+</sup> Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity. iScience. 2020 Jul 24;23(7):101263. doi: 10.1016/j.isci.2020.101263. Epub 2020 Jun 12. PMID: 32585596; PMCID: PMC7322071 PubMed

Philyppov IB, Sotkis GV, Rock A, Roudbaraki M, Bonnal JL, Mauroy B, Prevarskaya N, Shuba YM. Alterations in detrusor contractility in rat model of bladder cancer. Sci Rep. 2020 Nov 12;10(1):19651. doi: 10.1038/s41598-020-76653-7. PMID: 33184390; PMCID: PMC7665011 PubMed

Gkika D, Lolignier S, Grolez GP, Bavencoffe A, Shapovalov G, Gordienko D, Kondratskyi A, Meleine M, Prival L, Chapuy E, Etienne M, Eschalier A, Shuba Y, Skryma R, Busserolles J, Prevarskaya N. Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity. FASEB J. 2020 Jun;34(6):7483-7499. doi: 10.1096/fj.201902270R. Epub 2020 Apr 11. PMID: 32277850 PubMed

Haustrate A, Prevarskaya N, Lehen'kyi V. Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis. Cells. 2020 Jan 28;9(2):317. doi: 10.3390/cells9020317. PMID: 32013022; PMCID: PMC7072170 PubMed

 

2019

Grolez GP, Gordiendko DV, Clarisse M, Hammadi M, Desruelles E, Fromont G, Prevarskaya N, Slomianny C, Gkika D. TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration. Cell Death Dis. 2019 Sep 9;10(9):652. doi: 10.1038/s41419-019-1891-8. PubMed

Bernardini M, Brossa A, Chinigo G, Grolez GP, Trimaglio G, Allart L, Hulot A, Marot G, Genova T, Joshi A, Mattot V, Fromont G, Munaron L, Bussolati B, Prevarskaya N, Fiorio Pla A, Gkika D. Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis. Cancers (Basel). 2019 Jul 8;11(7). pii: E956. doi: 10.3390/cancers11070956. PubMed

Grolez GP, Hammadi M, Barras A, Gordienko D, Slomianny C, Völkel P, Angrand PO, Pinault M, Guimaraes C, Potier-Cartereau M, Prevarskaya N, Boukherroub R, Gkika D. Encapsulation of a TRPM8 Agonist, WS12, in Lipid Nanocapsules Potentiates PC3 Prostate Cancer Cell Migration Inhibition through Channel Activation. Sci Rep. 2019 May 28;9(1):7926. doi: 10.1038/s41598-019-44452-4. PubMed

Haustrate A, Hantute-Ghesquier A, Prevarskaya N, Lehen'kyi V. TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer. Cell Calcium. 2019 Jun;80:117-124. doi: 10.1016/j.ceca.2019.04.006. PubMed

Blanquart S, Borowiec AS, Delcourt P, Figeac M, Emerling CA, Meseguer AS, Roudbaraki M, Prevarskaya N, Bidaux G. Evolution of the human cold/menthol receptor, TRPM8. Mol Phylogenet Evol. 2019 Jul;136:104-118. doi: 10.1016/j.ympev.2019.04.011. PubMed

 

2018

Dubois C, Prevarskaya N. Western Blotting and Co-immunoprecipitation of Endogenous STIM/ORAI and Protein Partners. Methods Mol Biol. 2018;1843:107-113. doi: 10.1007/978-1-4939-8704-7_9. PubMed

Dubois C, Lehenkyi V, Prevarskaya N. CRAC Channel Components Quantitative Expression (In Tissues and Cell Lines) Using qPCR. Methods Mol Biol. 2018;1843:95-106. doi: 10.1007/978-1-4939-8704-7_8. PubMed

Vanden Abeele F, Lotteau S, Ducreux S, Dubois C, Monnier N, Hanna A, Gkika D, Romestaing C, Noyer L, Flourakis M, Tessier N, Al-Mawla R, Chouabe C, Lefai E, Lunardi J, Hamilton S, Fauré J, Van Coppenolle F, Prevarskaya N. TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. Genet Med. 2018 Jun 21. doi: 10.1038/s41436-018-0066-9.  PubMed

Noyer L, Grolez GP, Prevarskaya N, Gkika D, Lemonnier L. TRPM8 and prostate: a cold case? Pflugers Arch. 2018 Jun 20. doi: 10.1007/s00424-018-2169-1.  PubMed

Hantute-Ghesquier A, Haustrate A, Prevarskaya N, Lehen'kyi V. TRPM Family Channels in Cancer. Pharmaceuticals (Basel). 2018 Jun 7;11(2). pii: E58. doi: 10.3390/ph11020058.  PubMed

Bidaux G, Gordienko D, Shapovalov G, Farfariello V, Borowiec AS, Iamshanova O, Lemonnier L, Gueguinou M, Guibon R, Fromont G, Paillard M, Gouriou Y, Chouabe C, Dewailly E, Gkika D, López-Alvarado P, Carlos Menéndez J, Héliot L, Slomianny C, Prevarskaya N. 4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca2+ transfer. Biochim Biophys Acta. 2018 Apr 17. doi: 10.1016/j.bbamcr.2018.04.007.  PubMed

Prevarskaya N, Skryma R, Shuba Y. Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies? Physiol Rev. 2018 Apr 1;98(2):559-621. doi: 10.1152/physrev.00044.2016.  PubMed

 

2017

Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon RA, Slomianny C, Lemière S, Delcourt P, Dewailly E, Skryma R, Biot C, Prevarskaya N. Ferroquine, the next generation antimalarial drug, has antitumor activity. Sci Rep. 2017 Nov 21;7(1):15896. doi: 10.1038/s41598-017-16154-2.  PubMed

Shapovalov G, Ritaine A, Bidaux G, Slomianny C, Borowiec AS, Gordienko D, Bultynck G, Skryma R, Prevarskaya N. Organelle membrane derived patches: reshaping classical methods for new targets. Sci Rep. 2017 Oct 26;7(1):14082. doi: 10.1038/s41598-017-13968-y.  PubMed

Kondratskyi A, Kondratska K, Skryma R, Klionsky DJ, Prevarskaya N. Ion channels in the regulation of autophagy. Autophagy. 2017 Oct 5:0. doi: 10.1080/15548627.2017.1384887.  PubMed

Arredondo Zamarripa D, Noguez Imm R, Bautista Cortés AM, Vázquez Ruíz O, Bernardini M, Fiorio Pla A, Gkika D, Prevarskaya N, López-Casillas F, Liedtke W, Clapp C, Thébault S. Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. Sci Rep. 2017 Oct 12;7(1):13094. doi: 10.1038/s41598-017-13621-8.  PubMed

Ritaine A, Shapovalov G, Prevarskaya N. Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion. Adv Exp Med Biol. 2017;993:623-637. doi: 10.1007/978-3-319-57732-6_31.  PubMed

Nielsen N, Kondratska K, Ruck T, Hild B, Kovalenko I, Schimmelpfennig S, Welzig J, Sargin S, Lindemann O, Christian S, Meuth SG, Prevarskaya N, Schwab A. TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia. Pflugers Arch. 2017 Aug 28. doi: 10.1007/s00424-017-2057-0.  PubMed

Fliniaux I, Germain E, Farfariello V, Prevarskaya N. TRPs and Ca2+ in cell death and survival. Cell Calcium. 2017 Jul 15. pii: S0143-4160(17)30081-7. doi: 10.1016/j.ceca.2017.07.002.  PubMed

Genova T, Grolez GP, Camillo C, Bernardini M, Bokhobza A, Richard E, Scianna M, Lemonnier L, Valdembri D, Munaron L, Philips MR, Mattot V, Serini G, Prevarskaya N, Gkika D, Pla AF. TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1.J Cell Biol. 2017 May 26. pii: jcb.201506024. doi: 10.1083/jcb.201506024.  PubMed

Monteith GR, Prevarskaya N, Roberts-Thomson SJ. The calcium-cancer signalling nexus. Nat Rev Cancer. 2017 Jun;17(6):367-380. doi: 10.1038/nrc.2017.18.  PubMed

Iamshanova O, Fiorio Pla A, Prevarskaya N. Molecular mechanisms of tumor invasion: regulation by calcium signals. J Physiol. 2017 Mar 17. doi: 10.1113/JP272844.  PubMed

Vancauwenberghe E, Noyer L, Derouiche S, Lemonnier L, Gosset P, Sadofsky LR, Mariot P, Warnier M, Bokhobza A, Slomianny C, Mauroy B, Bonnal JL, Dewailly E, Delcourt P, Allart L, Prevarskaya N, Roudbaraki M. Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Mol Carcinog. 2017 Mar 9. doi: 10.1002/mc.22642. PubMed

Derouiche S, Mariot P, Warnier M, Vancauwenberghe E, Bidaux G, Gosset P, Mauroy B, Bonnal JL, Slomianny C, Delcourt P, Dewailly E, Prevarskaya N, Roudbaraki M. Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells. Cancer Prev Res (Phila). 2017 Jan 17. doi: 10.1158/1940-6207.CAPR-16-0257. PubMed

 

2016

Iamshanova O, Mariot P, Lehen'kyi V, Prevarskaya N. Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines. Eur Biophys J. 2016 Oct;45(7):765-777. PubMed PMID: 27660079; PubMed Central PMCID: PMC5045488.

Ivanova H, Ritaine A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G. The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition. Oncotarget. 2016 Aug 2:55704-55720. doi: 10.18632/oncotarget.11005. PubMed PMID: 27494888.

Grolez GP, Gkika D. TRPM8 Puts the Chill on Prostate Cancer.  Pharmaceuticals (Basel). 2016 Jul 9;9(3). pii: E44. doi: 10.3390/ph9030044. Review. PMID: 27409624

Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, Jégou B, Prevarskaya N, Bidaux G. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. FASEB J. 2016 Sep;30(9):3155-70. doi: 10.1096/fj.201600257R. PubMed PMID: 27317670; PubMed Central PMCID: PMC5001517.

Bidaux G, Borowiec AS, Dubois C, Delcourt P, Schulz C, Vanden Abeele F, Lepage G, Desruelles E, Bokhobza A, Dewailly E, Slomianny C, Roudbaraki M, Héliot L, Bonnal JL, Mauroy B, Mariot P, Lemonnier L, Prevarskaya N. Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Oncotarget. 2016 May 17;7(20):29063-80. doi: 10.18632/oncotarget.8666. PubMed PMID: 27074561; PubMed Central PMCID: PMC5045378.

Bidaux G, Borowiec AS, Prevarskaya N, Gordienko D. Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate. Channels (Austin). 2016 Jul 3;10(4):320-31. doi: 10.1080/19336950.2016.1168551. PubMed PMID: 27014839; PubMed Central PMCID: PMC4954583.

Philyppov IB, Paduraru ON, Gulak KL, Skryma R, Prevarskaya N, Shuba YM. TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats.  Smooth Muscle Res. 2016;52:1-17. doi:10.1540/jsmr.52.1. PubMed PMID: 26935999.

Shapovalov G, Ritaine A, Skryma R, Prevarskaya N. Role of TRP ion channels in cancer and tumorigenesis. Semin Immunopathol. 2016 May;38(3):357-69. doi:10.1007/s00281-015-0525-1. Review. PubMed PMID: 26842901.

Fiorio Pla A, Kondratska K, Prevarskaya N. STIM and ORAI proteins: crucial roles in hallmarks of cancer. Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C509-19. doi: 10.1152/ajpcell.00364.2015. Review. PubMed PMID: 26791491.

 

2015

Bernardini M, Fiorio Pla A, Prevarskaya N, Gkika D. Human transient receptor potential (TRP) channel expression profiling in carcinogenesis. Int J Dev Biol. 2015;59(7-9):399-406. doi: 10.1387/ijdb.150232dg. Review. PubMed PMID: 26679952.

Dubois C, Prevarskaya N, Vanden Abeele F. The calcium-signaling toolkit: Updates needed. Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1337-43. doi: 10.1016/j.bbamcr.2015.11.033. Review. PubMed PMID: 26658643.

Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N. Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3345-54. doi: 10.1073/pnas.1423357112. PubMed PMID: 26080404; PubMed  Central PMCID: PMC4491737.

Smani T, Shapovalov G, Skryma R, Prevarskaya N, Rosado JA. Functional and physiopathological implications of TRP channels. Biochim Biophys Acta. 2015 Aug;1853(8):1772-82. doi: 10.1016/j.bbamcr.2015.04.016. Review. PubMed PMID: 25937071.

Dubois C, Vanden Abeele F, Prevarskaya N. [A new oncogenic switch in prostate cancer progression: the exceptional ORAI3]. Med Sci (Paris). 2015 Mar;31(3):244-7. doi: 10.1051/medsci/20153103006. French. PubMed PMID: 25855274.

Vanden Abeele F, Dubois C, Shuba Y, Prevarskaya N. Disrupting the dynamic equilibrium of ORAI channels determines the phenotype of malignant cells. Mol Cell Oncol. 2015 Jan 21;2(2):e975631. doi: 10.4161/23723556.2014.975631. PubMed PMID: 27308432; PubMed Central PMCID: PMC4904888.

Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N. Calcium homeostasis in cancer: A focus on senescence. Biochim Biophys Acta. 2015 Sep;1853(9):1974-9. doi: 10.1016/j.bbamcr.2015.03.005. Review. PubMed PMID:25764980.

Warnier M, Roudbaraki M, Derouiche S, Delcourt P, Bokhobza A, Prevarskaya N, Mariot P. CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis. Oncogene. 2015 Oct 16;34(42):5383-94. doi: 10.1038/onc.2014.467. PubMed PMID: 25619833.

Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, Bokhobza A, Bidaux G, Degerny C, Verreman K, Guarmit B, Benahmed M, de Launoit Y, Bindels RJ, Fiorio Pla A, Prevarskaya N. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol. 2015 Jan 5;208(1):89-107. doi: 10.1083/jcb.201402076. PubMed PMID: 25559186; PubMed Central PMCID: PMC4284226.

Gordienko D, Povstyan O, Sukhanova K, Raphaël M, Harhun M, Dyskina Y, Lehen'kyi V, Jama A, Lu ZL, Skryma R, Prevarskaya N. Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension. Cardiovasc Res. 2015 Feb 1;105(2):131-42. doi: 10.1093/cvr/cvu249. PubMed PMID: 25514930.

Fiorio Pla A, Brossa A, Bernardini M, Genova T, Grolez G, Villers A, Leroy X, Prevarskaya N, Gkika D, Bussolati B. Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib. BMC Cancer. 2014 Dec 12;14:939. doi: 10.1186/1471-2407-14-939. PubMed PMID: 25494980; PubMed Central PMCID: PMC4295225.

Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N. Ion channels in the regulation of apoptosis. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2532-46. doi: 10.1016/j.bbamem.2014.10.030. Review. PubMed PMID: 25450339.

 

2014

Raphaël M, Lehen'kyi V, Vandenberghe M, Beck B, Khalimonchyk S, Vanden Abeele F, Farsetti L, Germain E, Bokhobza A, Mihalache A, Gosset P, Romanin C, Clézardin P, Skryma R, Prevarskaya N. TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3870-9. doi: 10.1073/pnas.1413409111. PubMed PMID: 25172921; PubMed Central PMCID: PMC4169956.

Dubois C, Vanden Abeele F, Lehen'kyi V, Gkika D, Guarmit B, Lepage G, Slomianny C, Borowiec AS, Bidaux G, Benahmed M, Shuba Y, Prevarskaya N. Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer. Cancer Cell. 2014 Jul 14;26(1):19-32. doi: 10.1016/j.ccr.2014.04.025. PubMed PMID: 24954132.

Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun. 2014 May 6;5:3792. doi: 10.1038/ncomms4792. PubMed PMID: 24797322.

Kondratskyi A, Yassine M, Slomianny C, Kondratska K, Gordienko D, Dewailly E, Lehen'kyi V, Skryma R, Prevarskaya N. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 2014 Apr 24;5:e1193.
doi: 10.1038/cddis.2014.156. PubMed PMID: 24763050; PubMed Central PMCID:PMC4001310.

Kondratska K, Kondratskyi A, Yassine M, Lemonnier L, Lepage G, Morabito A, Skryma R, Prevarskaya N. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma. Biochim Biophys Acta. 2014 Oct;1843(10):2263-9. doi: 10.1016/j.bbamcr.2014.02.012. PubMed PMID: 24583265.

Prevarskaya N, Ouadid-Ahidouch H, Skryma R, Shuba Y. Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks? Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130097. doi: 10.1098/rstb.2013.0097. Review. PubMed PMID: 24493745; PubMed Central PMCID: PMC3917351.

 

2013

Vandenberghe M, Raphaël M, Lehen'kyi V, Gordienko D, Hastie R, Oddos T, Rao A, Hogan PG, Skryma R, Prevarskaya N. ORAI1 calcium channel orchestrates skin homeostasis. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4839-48. doi:10.1073/pnas.1310394110. PubMed PMID: 24277812; PubMed Central PMCID: PMC3864283.

Gackière F, Warnier M, Katsogiannou M, Derouiche S, Delcourt P, Dewailly E, Slomianny C, Humez S, Prevarskaya N, Roudbaraki M, Mariot P. Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium
channels participates in prostate cancer cell growth. Biol Open. 2013 Jul 26;2(9):941-51. doi: 10.1242/bio.20135215. PubMed PMID: 24143281; PubMed Central PMCID: PMC3773341.

Kondratskyi A, Yassine M, Kondratska K, Skryma R, Slomianny C, Prevarskaya N. Calcium-permeable ion channels in control of autophagy and cancer. Front Physiol. 2013 Oct 2;4:272. doi: 10.3389/fphys.2013.00272. PubMed PMID: 24106480; PubMed Central PMCID: PMC3788328.

Vanden Abeele F, Kondratskyi A, Dubois C, Shapovalov G, Gkika D, Busserolles J, Shuba Y, Skryma R, Prevarskaya N. Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia. J Cell Sci. 2013 Oct 1;126(Pt 19):4479-89. doi: 10.1242/jcs.131631. PubMed PMID: 23943870.

Dubois C, Vanden Abeele F, Sehgal P, Olesen C, Junker S, Christensen SB, Prevarskaya N, Møller JV. Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium. FEBS J. 2013 Nov;280(21):5430-40. doi: 10.1111/febs.12475. PubMed PMID: 23927406.

Shapovalov G, Gkika D, Devilliers M, Kondratskyi A, Gordienko D, Busserolles J, Bokhobza A, Eschalier A, Skryma R, Prevarskaya N. Opiates modulate thermosensation by internalizing cold receptor TRPM8. Cell Rep. 2013 Aug 15;4(3):504-15. doi: 10.1016/j.celrep.2013.07.002. PubMed PMID: 23911290.

Oulidi A, Bokhobza A, Gkika D, Vanden Abeele F, Lehen'kyi V, Ouafik L, Mauroy B, Prevarskaya N. TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion. PLoS One. 2013 May
31;8(5):e64885. doi: 10.1371/journal.pone.0064885. PubMed PMID: 23741410; PubMed Central PMCID: PMC3669125.

Dubois C, Vanden Abeele F, Prevarskaya N. Targeting apoptosis by the remodelling of calcium-transporting proteins in cancerogenesis. FEBS J. 2013 Nov;280(21):5500-10. doi: 10.1111/febs.12246. Review. PubMed PMID: 23497199.

Fioro Pla A and Gkika D. Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis. Front. Physiol. 2013 Nov 5;4:311. doi: 10.3389/fphys.2013.00311. PMID: 24204345

Derouiche S, Warnier M, Mariot P, Gosset P, Mauroy B, Bonnal JL, Slomianny C, Delcourt P, Prevarskaya N, Roudbaraki M. Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling. Springerplus. 2013
Dec;2(1):54. doi: 10.1186/2193-1801-2-54. PubMed PMID: 23450760; PubMed Central PMCID: PMC3581770.

Hammadi M, Oulidi A, Gackière F, Katsogiannou M, Slomianny C, Roudbaraki M, Dewailly E, Delcourt P, Lepage G, Lotteau S, Ducreux S, Prevarskaya N, Van Coppenolle F. Modulation of ER stress and apoptosis by endoplasmic reticulum
calcium leak via translocon during unfolded protein response: involvement of GRP78. FASEB J. 2013 Apr;27(4):1600-9. doi: 10.1096/fj.12-218875. PubMed PMID: 23322163.

Prevarskaya N, Skryma R, Shuba Y. Targeting Ca²⁺ transport in cancer: close reality or long perspective? Expert Opin Ther Targets. 2013 Mar;17(3):225-41. doi: 10.1517/14728222.2013.741594. Review. PubMed PMID: 23294334.

Vanoverberghe K, Lehen'kyi V, Thébault S, Raphaël M, Vanden Abeele F, Slomianny C, Mariot P, Prevarskaya N. Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells. PLoS One. 2012;7(9):e45615. doi:10.1371/journal.pone.0045615. PubMed PMID: 23049826; PubMed Central PMCID: PMC3458093.

Shapovalov G, Skryma R, Prevarskaya N. Calcium channels and prostate cancer. Recent Pat Anticancer Drug Discov. 2013 Jan 1;8(1):18-26. Review. PubMed PMID:22694290.

 

2012

Lehen'kyi V, Raphaël M, Prevarskaya N. The role of the TRPV6 channel in cancer. J Physiol. 2012 Mar 15;590(6):1369-76. doi: 10.1113/jphysiol.2011.225862. Review. PubMed PMID: 22331416; PubMed Central PMCID: PMC3382328.

Bidaux G, Beck B, Zholos A, Gordienko D, Lemonnier L, Flourakis M, Roudbaraki M, Borowiec AS, Fernández J, Delcourt P, Lepage G, Shuba Y, Skryma R, Prevarskaya N. Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. J Biol Chem. 2012 Jan 27;287(5):2948-62. doi: 10.1074/jbc.M111.270256. PubMed PMID: 22128173; PubMed Central PMCID: PMC3270952.

Fernández JA, Skryma R, Bidaux G, Magleby KL, Scholfield CN, McGeown JG, Prevarskaya N, Zholos AV. Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors. J Biol Chem. 2012 Jan 27;287(5):2963-70. doi: 10.1074/jbc.M111.272823. PubMed PMID: 22128172; PubMed Central PMCID: PMC3270953.

 

2011

Lehen′kyi V, Prevarskaya N. Study of TRP Channels in Cancer Cells. In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 17. PubMed PMID: 22593971.

Firlej V, Mathieu JR, Gilbert C, Lemonnier L, Nakhlé J, Gallou-Kabani C, Guarmit B, Morin A, Prevarskaya N, Delongchamps NB, Cabon F. Thrombospondin-1 triggers cell migration and development of advanced prostate tumors. Cancer Res. 2011 Dec 15;71(24):7649-58. doi: 10.1158/0008-5472.CAN-11-0833. PubMed PMID: 22037878.

Skryma R, Prevarskaya N, Gkika D, Shuba Y. From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. Nat Rev Urol. 2011 Oct 4;8(11):617-30. doi: 10.1038/nrurol.2011.142. Review. PubMed PMID: 21971315.

Lehen'kyi V, Shapovalov G, Skryma R, Prevarskaya N. Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis. Am J Physiol Cell Physiol. 2011 Dec;301(6):C1281-9. doi: 10.1152/ajpcell.00249.2011. Review. PubMed PMID: 21940667.

Prevarskaya N, Skryma R, Shuba Y. Calcium in tumour metastasis: new roles for known actors. Nat Rev Cancer. 2011 Jul 22;11(8):609-18. doi: 10.1038/nrc3105. Review. PubMed PMID: 21779011.

Shapovalov G, Lehen'kyi V, Skryma R, Prevarskaya N. TRP channels in cell survival and cell death in normal and transformed cells. Cell Calcium. 2011 Sep;50(3):295-302. doi: 10.1016/j.ceca.2011.05.006. Review. PubMed PMID: 21628069.

Gkika D, Prevarskaya N. TRP channels in prostate cancer: the good, the bad and the ugly? Asian J Androl. 2011 Sep;13(5):673-6. doi: 10.1038/aja.2011.18. PubMed PMID: 21623387; PubMed Central PMCID: PMC3739589.

Lehen'kyi V, Raphaël M, Oulidi A, Flourakis M, Khalimonchyk S, Kondratskyi A, Gordienko DV, Mauroy B, Bonnal JL, Skryma R, Prevarskaya N. TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth. PLoS One. 2011 Feb 11;6(2):e16856. doi: 10.1371/journal.pone.0016856. PubMed PMID: 21347289; PubMed Central PMCID: PMC3037935.

Lehen'kyi V, Prevarskaya N. Oncogenic TRP channels. Adv Exp Med Biol. 2011;704:929-45. doi: 10.1007/978-94-007-0265-3_48. Review. PubMed PMID: 21290334.

Fernández JA, Skryma R, Bidaux G, Magleby KL, Scholfield CN, McGeown JG, Prevarskaya N, Zholos AV. Voltage- and cold-dependent gating of single TRPM8 ion channels. J Gen Physiol. 2011 Feb;137(2):173-95. doi: 10.1085/jgp.201010498.
PubMed PMID: 21282398; PubMed Central PMCID: PMC3032375.

Bavencoffe A, Kondratskyi A, Gkika D, Mauroy B, Shuba Y, Prevarskaya N, Skryma R. Complex regulation of the TRPM8 cold receptor channel: role of arachidonic acid release following M3 muscarinic receptor stimulation. J Biol Chem. 2011 Mar 18;286(11):9849-55. doi: 10.1074/jbc.M110.162016. PubMed PMID: 21245133; PubMed Central PMCID: PMC3059061.

Lehen'kyi V, Vandenberghe M, Belaubre F, Julié S, Castex-Rizzi N, Skryma R, Prevarskaya N. Acceleration of keratinocyte differentiation by transient receptor potential vanilloid (TRPV6) channel activation. J Eur Acad Dermatol Venereol. 2011 Feb;25 Suppl 1:12-8. doi: 10.1111/j.1468-3083.2010.03894.x. PubMed PMID: 21175869.

 

2010

Flourakis M, Lehen'kyi V, Beck B, Raphaël M, Vandenberghe M, Abeele FV, Roudbaraki M, Lepage G, Mauroy B, Romanin C, Shuba Y, Skryma R, Prevarskaya N. Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells. Cell Death Dis. 2010 Sep 16;1:e75. doi: 10.1038/cddis.2010.52. PubMed PMID: 21364678; PubMed Central PMCID: PMC3032347.

Gkika D, Flourakis M, Lemonnier L, Prevarskaya N. PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression. Oncogene. 2010 Aug 12;29(32):4611-6. doi: 10.1038/onc.2010.210. PubMed PMID:
20531306.

El Boustany C, Katsogiannou M, Delcourt P, Dewailly E, Prevarskaya N, Borowiec AS, Capiod T. Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells. Cell Calcium. 2010 Apr;47(4):350-9. doi: 10.1016/j.ceca.2010.01.006. PubMed PMID: 20172609.

Prevarskaya N, Skryma R, Shuba Y. Ion channels and the hallmarks of cancer. Trends Mol Med. 2010 Mar;16(3):107-21. doi: 10.1016/j.molmed.2010.01.005. Review. PubMed PMID: 20167536.

Bavencoffe A, Gkika D, Kondratskyi A, Beck B, Borowiec AS, Bidaux G, Busserolles J, Eschalier A, Shuba Y, Skryma R, Prevarskaya N. The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway. J Biol Chem. 2010 Mar 26;285(13):9410-9. doi: 10.1074/jbc.M109.069377. PubMed PMID: 20110357; PubMed Central PMCID: PMC2843190.

Monet M, Lehen'kyi V, Gackiere F, Firlej V, Vandenberghe M, Roudbaraki M, Gkika D, Pourtier A, Bidaux G, Slomianny C, Delcourt P, Rassendren F, Bergerat JP, Ceraline J, Cabon F, Humez S, Prevarskaya N. Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 2010 Feb 1;70(3):1225-35. doi: 10.1158/0008-5472.CAN-09-2205. PubMed  PMID: 20103638.