V'yacheslav LEHEN'KYI, PhD, HDR
Dr. V'yacheslav LEHEN'KYI is an alumni of the University of Taras Shevchenko, Biological faculty, Department of Biochemistry. In October 2001 he obtained his PhD in Pharmacology in the Laboratory of Experimental Therapy, at the Research Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine. His PhD work concerned the sensitivity of the vascular smooth muscle contractile machinery to the NO action. In 2002-2003 he did his first postdoc in the Laboratory of Molecular and Cell Cardiology headed by Dr. Rodolphe Fischmeister, at the University of Paris XI where he studied small GTPase Rac1 and CDC42 effects of cardiac hypertrophy. His second postdoc he continued in Kyiv where he studied the cGMP-independent effects of NO on the arterial smooth muscles. Dr. V'yacheslav LEHEN'KYI joined our Laboratory in 2004 as a postdoctoral researcher to study the mechanisms where such TRP calcium channels as TRPV6, TRPV2, TRPC1-6, in adition to the calcium channel Orai1 and ER calcium sensor STIM1, are involved in the prostate cancer. During 2004-2015 his second research project related to the role of the above channels in the skin homeostasis such as a balance of proliferation, differentiation, migration and senescence.
Today, Dr. Dr. V'yacheslav LEHEN'KYI is responsible for the research Axis:
- Ion Channel Therapeutic Antibody Design and Tumor Targeting in vivo (project funded by SATT du Nord at the level of 480 000€ for 3 years).
- Role Of The Calcium Channel TRPV6 In The Development Of The Bone Metastasis In Prostate Cancer (project funded by “Ligue Contre Cancer” at the level of 40 000€ /year for 3 years).