Our publications

2012/01 Tamoutounour S, Henri S, Lelouard H, de Bovis B, de Haar C, van der Woude CJ, Woltman AM, Reyal Y, Bonnet D, Sichien D, Bain CC, Mowat AM, Reis e Sousa C, Poulin LF, Malissen B, Guilliams M. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur J Immunol. 2012 Dec;42(12):3150-66.

2012/02 Poulin LF, Reyal Y, Uronen-Hansson H, Schraml BU, Sancho D, Murphy KM, Håkansson UK, Moita LF, Agace WW, Bonnet D, Reis e Sousa C. DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood. 2012 Jun 21;119(25):6052-62.

2013/01 Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P, Chamaillard M. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J. Clin. Invest. 123(2), 700–711.

2013/02 Ubelmann F, Chamaillard M, El-Marjou F, Simon A, Netter J, Vignjevic D, Nichols BL, Quezada-Calvillo R, Grandjean T, Louvard D, Revenu C and Robine S. Enterocyte loss of Q:1; 2 polarity and gut wound healing rely upon the F-actin–severing function of villin. Proc Natl Acad Sci U S A. 110(15), E1380-9.

2013/03 Sedhom MA, Pichery M, Murdoch JR, Foligné B, Ortega N, Normand S, Mertz K, Sanmugalingam D, Brault L, Grandjean T, Lefrancais E, Fallon PG, Quesniaux V, Peyrin-Biroulet L, Cathomas G, Junt T*, Chamaillard M*, Girard JP*, Ryffel B*. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. GUT. 2013 Dec;62(12):1714-23 (* shared senior authorship).

2014/01 Faure E, Mear JB, Faure K, Normand S, Couturier-Maillard A, Grandjean T, Balloy V, Ryffel B, Dessein R, Chignard M, Uyttenhove C, Guery B, Gosset P, Chamaillard M*, Kipnis E*. Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome. Am J Respir Crit Care Med. 2014 Apr 1;189(7):799-811 (* shared senior authorship).

2014/02 Ait Yahia S, Azzaoui I, Everaere L, Vorng H, Chenivesse C, Marquillies P, Duez C, Delacre M, Grandjean T, Balsamelli J, Fanton d'Andon M, Fan Y, Ple C, Werts C, Boneca IG, Wallaert B, Chamaillard M, Tsicopoulos A. CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma. Am J Respir Crit Care Med. 2014 Apr 15;189(8):899-908.

2015/01 Lévy J, Cacheux W, Ait-Bara M, L'hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, Marchiol C, Renault G, Dumont F, Letourneur F, Delacre M, Schmitt A, Terris B, Perret C, Chamaillard M*, Couty JP*, Romagnolo B. Intestinal inhibition of Atg7 prevents tumor initiation through a microbiome-influenced immune response and suppresses tumor growth. Nat Cell Biol 2015 Aug;17(8):1062-73 (*contributed equally).

2015/02 Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Bérard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 350(6264):1079-84.

2016/01 Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A and Rosenstiel P. Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation. Cell Rep. 2016 Aug 23;16(8):2208-18.

2016/02 Daillère R, Vétizou M, Waldschmitt N, Yamazaki T, Isnard C, Poirier-Colame V, Duong CP, Flament C, Lepage P, Roberti MP, Routy B, Jacquelot N, Apetoh L, Becharef S, Rusakiewicz S, Langella P, Sokol H, Kroemer G, Enot D, Roux A, Eggermont A, Tartour E, Johannes L, Woerther PL, Chachaty E, Soria JC, Golden E, Formenti S, Plebanski M, Madondo M, Rosenstiel P, Raoult D, Cattoir V, Boneca IG, Chamaillard M, Zitvogel L. Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943

2017/01 Guinet-Charpentier C, Lepage P, Morali A, Chamaillard M, Peyrin-Biroulet L. Effects of enteral polymeric diet on gut microbiota in children with Crohn's disease. GUT. 2017 Jan;66(1):194-195.

2017/02 De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine, S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse, E. Hemidesmosome integrity protects the colon against colitis and colorectal cancer. GUT., 2017 Oct;66(10):1748-1760.

2017/03 Yadav P, Ellinghaus D, Rémy G, Freitag-Wolf S, Cesaro A, Degenhardt F, Boucher G, Delacre M, International IBD Genetics Consortium, Peyrin-Biroulet L, Pichavant M, Rioux JD, Gosset P, Franke A, Schumm LP, Krawczak M, Chamaillard M*, Dempfle A*, Andersen V*. Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice. Gastroenterology., 2017 Aug;153(2):550-565 (*Shared last authorship).

2017/04 Lamas B, Michel ML, Waldschmitt N, Pham HP, Zacharioudaki V, Dupraz L, Delacre M, Natividad JM, Costa GD, Planchais J, Sovran B, Bridonneau C, Six A, Langella P, Richard ML, Chamaillard M, Sokol H. Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence. GUT., 2017 Aug 8. pii: gutjnl-2017-314195. doi:10.1136/gutjnl-2017-314195.

2017/05 Radulovic K, Normand S, Rehman A, Delanoye-Crespin A, Chatagnon J, Delacre M, Waldschmitt N, Poulin LF, Iovanna J, Ryffel B, Rosenstiel P, Chamaillard M. A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. Mucosal Immunol., 2017 Nov 15. doi: 10.1038/mi.2017.87.

2017/06 Lasseaux C, Fourmaux MP, Chamaillard M, Poulin LF. Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia. Sci Rep., 2017 Dec 5;7(1):16935.

2018/01 Plantamura E, Dzutsev A, Chamaillard M, Djebali S, Moudombi L, Boucinha L, Grau M, Macari C, Bauché D, Dumitrescu O, Rasigade JP, Lippens S, Plateroti M, Kress E, Cesaro A, Bondu C, Rothermel U, Heikenwälder M, Lina G, Bentaher-Belaaouaj A, Marie JC, Caux C, Trinchieri G, Marvel J, Michallet MC. MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10404-10409.

2018/02 Waldschmitt N, Kitamoto S, Secher T, Zacharioudaki V, Boulard O, Floquet E, Delacre M, Lamas B, Pham HP, Six A, Richard ML, Dagorn JC, Eberl G, Langella P, Chatel JM, Ryffel B, Iovanna JL, Poulin LF, Sokol H, Kamada N, Chamaillard M. The Regenerating Family Member 3 beta instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signaling for controlling colonization resistance independently of microbiota community structure. GUT. 2018 Oct 2. pii: gutjnl-2018-316757.

2018/03 Hara H, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, Núñez G. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Oct 26. pii: S0092-8674(18)31259-5. doi: 10.1016/j.cell.2018.09.047.

2018/04 Normand S, Waldschmitt N, Neerincx A, Martinez-Torres J, Chauvin C, Couturier-Maillard A, Boulard O, Cobret L, Awad F, Huot L, Ribeiro-Ribeiro A, Lautz K, Ruez R, Delacre M, Bondu C, Guilliams M, Scott C, Segal A, Amselem S, Hot D, Karabina S,  Bohn E, Ryffel B, Poulin LF, Kufer TA, Chamaillard M. Proteosomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogen. Nat Commun. In press.

 

News & Views: Nature Medicine: "A needle in the 'cancer vaccine' haystack"

News & Views: Nature Biotechnology: "The expanding family of dendritic cell subsets"

Research Highlight: Nature Reviews Immunology:"New DCs found deep in the skin"

Inserm Science et Santé: Maladie de Crohn : Les probiotiques à la rescousse

La Croix du Nord: le microbiote intestinal, allié contre le cancer et la maladie de Crohn

France Culture: Microbiote : ces bactéries qui nous veulent du bien

BFMTV: Des bactéries du microbiote pourraient booster l'efficacité des chimiothérapies

Inserm Newsroom: La flore intestinale en renfort de l'immunothérapie en cancérologie

Inserm Newsroom: Le microbiote intestinal à la rescousse des chimiothérapies

Bel RTL: Santé vous bien

CNRS: Décryptage du lien entre microbiote intestinal et allergie cutanée

Inserm Newsroom: A l’origine d’une maladie rare, un intestin frileux et intolérant à ses propres bactéries

 

En direct du JT @F3nord pour parler de la maladie de #Crohn avec Mathias Chamaillard, chercheur @PasteurLille pr les 70 ans de @frm_medical

 

Conferences

Conference Collège de France: "Microbiota, Nutrition and Metabolism", 03 June 2014

Conference Cité des Sciences et de l'Industrie: "Flore Intestinale, un équilibre fragile à préserver", 01 june 2017

Conference Forum du CNRS: "Les secrets du microbiote intestinal"

Symposium PiLèJe: "La Médecine des Microbiotes, de la recherche aux innovations thérapeutiques"

 

Grants and collaborations

2019/21 ANR, “InnovAsthma: Déterminants moléculaires de sensibilisation à l'asthme allergique et innovation thérapeutique” (ANR-18-CE14-0020-02) (Mathias Chamaillard)

2018/19 Association François Aupetit, “Rôle des macrophages sur le développement des sténoses intestinales au cours de la maladie de Crohn” (Lionel F. Poulin)

2017/19 Plan Cancer 2014-19, "Integrating the intra-tumoral microbiome to promote understanding on tumor plasticity" (Mathias Chamaillard).

2017/19 FEDER EIRC Etude de l'impact du rythme circadien sur le risque de tumorigénèse intestinale: vers une nouvelle approche en chronopharmacologie (Mathias Chamaillard)

2016 Programme transversal Microbiote Inserm 2016 (Mathias Chamaillard)

2015/17 Association de Recherche contre le Cancer, "Impact of gut microbiota in the response to anticancer therapeutics" (Mathias Chamaillard)