Natalia Prevarskaya, PhD
Natalia Prevarskaya is Professor of Physiology at the University of Lille, France. She is the director of the Cell Physiology Unit, INSERM U1003, certified by the INSERM (National Institute for Health and Medical Research). Her group is part of the Laboratory of Excellence in Ion Channels Science and Therapeutics. She leads the "Calcium signatures of prostate cancer" team certified by the National League Against Cancer. Her scientific interests include the function and regulation of ion channels and the role of ion channels and calcium signaling in carcinogenesis. She is author of more than 150 publications and obtained a number of prestigious prices and grants.
Ingrid Fliniaux, PhD
Emmanuelle Germain, PhD
Dimitra Gkika, PhD
Dimitra Gkika obtained her PhD in Medical Sciences in 2006 from Radboud University Medical Centre Nijmegen (the Netherlands). She was then awarded with an EMBO Long-Term Fellowships for postdoctoral research on TRP channels implication in physiopathology and was subsequently recruited as an Associate Professor in Lille University in 2009. During her research activity, she developed a long-standing expertise on TRP channels and their role in renal ion transport, thermosensation, pain sensibility, carcinogenesesis and tumor angiogenesis, the results of which are described in high impact international peer-reviewed journals (J Cell Biol, Cancer Res, EMBO J, J Clin Invest and Oncogene) and presented upon invitation in prestigious international meetings (Gordon Conferences, SfN and European Physiology Societies meetings). She recently initiated a novel research axis on TRP involvement in cell migration and angiogenesis during carcinogenesis that was evaluated as one of the two most promising axes of the Inserm U1003 by the French Evaluation Agency for Research and Higher Education (AERES 2014). With this project, she participates in the French network of excellence (LabEx) on the topic of channelopathies. To support her research, she raised several grants such as INCa 2014-2018, ARTP 2014-2015, ARC 2015-2016 and stipends for international PhD students (Vinci Project Université Franco-Italienne 2012-2015). She is teaching in the University of Lille Physiology, Cell Biology, Cell Physiology and Biotechnologies, while she actively participates in the bilingual teaching since its beginning in 2013. She regularly tutors students for their trainee during the last year of the bachelor as well as the two years of the master (for which she established an Erasmus + program with Turin University) and the PhD training.
V'yacheslav Lehen'kyi, PhD
Dr. V'yacheslav LEHEN'KYI is an alumni of the University of Taras Shevchenko, Biological faculty, Department of Biochemistry. In October 2001 he obtained his PhD in Pharmacology in the Laboratory of Experimental Therapy, at the Research Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine. His PhD work concerned the sensitivity of the vascular smooth muscle contractile machinery to the NO action. In 2002-2003 he did his first postdoc in the Laboratory of Molecular and Cell Cardiology headed by Dr. Rodolphe Fischmeister, at the University of Paris XI where he studied small GTPase Rac1 and CDC42 effects of cardiac hypertrophy. His second postdoc he continued in Kyiv where he studied the cGMP-independent effects of NO on the arterial smooth muscles. Dr. V'yacheslav LEHEN'KYI joined our Laboratory in 2004 as a postdoctoral researcher to study the mechanisms where such TRP calcium channels as TRPV6, TRPV2, TRPC1-6, in adition to the calcium channel Orai1 and ER calcium sensor STIM1, are involved in the prostate cancer. During 2004-2015 his second research project related to the role of the above channels in the skin homeostasis such as a balance of proliferation, differentiation, migration and senescence.
Today, Dr. Dr. V'yacheslav LEHEN'KYI is responsible for the research Axis:
- Ion Channel Therapeutic Antibody Design and Tumor Targeting in vivo (project funded by SATT du Nord at the level of 480 000€ for 3 years).
- Role Of The Calcium Channel TRPV6 In The Development Of The Bone Metastasis In Prostate Cancer (project funded by “Ligue Contre Cancer” at the level of 40 000€ /year for 3 years).
Pascal Mariot, PhD
Pascal Mariot obtained his PhD in Life Sciences (Neurosciences and Pharmacology) from the University of Bordeaux II, in September 1993. During his PhD, he focused his studies on the role of ion channels and proton transporters in the secretion of pituitary hormones. He then joined in September 1993 the Department of Physiology at University College London for 3 years (1993-1996) , where he studied GTP-dependent mast cell degranulation using membrane capacitance monitoring. From 1996 to 1997, he obtained a post-doctoral position at the University Catholique de Louvain (UCL, Belgium) in the department of endocrinology (Brussels, Hopital Saint Luc), and worked on the role of voltage-dependent Ca channels and ATP-dependent K channels in insulin secretion. He is a permanent member of the laboratory of Cell Physiology, Lille since September 1997, where he works as an Associate Professor to investigate the mechanisms, and noticeably the role of T-type calcium channels, involved in prostate cancer cell carcinoma progression.
George Shapovalov, PhD
George Shapovalov has done his PhD at California Institute of Technology, applying biophysical methods to study mechanosensitive channels at single- channel methods, working on isolated as well as synthesyzed proteins reconstituted in artificial liposomes. He continued his activities as a postdoc in University of Geneva, studying role of various ion channels in Duchene Muscular Dystrophy. He entered our laboratory as a postdoc in July of 2010 and became as Associate Professor in Sept 2014. His research covered topics ranging from studying role of TRP channels in prostate cancer progression to development of approaches to study intracellular ion channels and their regulation by endogenous protein partners.
Christophe Tastet, PhD
Christophe Tastet obtained his PhD in Proteomics from Ecole Normale Supérieure Agronomique de Rennes in May 2000. During his PhD (INRA), he focused on the application of a putative fatty-acid binding protein to discriminate serologically two European quarantine phytoparasites from other species by means of two-dimensional electrophroregram (2D IEF/SDS-PAGE) computed analysis. In 2001, he was a postdoctoral fellow in the laboratory of Dr Thierry Rabilloud at the Commissariat à l'Energie Atomique (CEA, Grenoble) where he has specialized in protein solubilisation and extraction, with a focus on membrane proteins.
Then, he completed a second postdoctoral fellowship in proteomics applied to Parasitolgy (Malaria) at the CNRS Montpellier under the supervision of Drs Henri Vial and Jean-françois Dubremetz. Recruited in 2005 as Assistant professor (Maître de Conférences) in the laboratory INSERM u908 « Signalisation des facteurs de croissance dans le cancer du sein - Protéomique fonctionnelle) managed by Pr Hubert Hondermarck; he joined our laboratory (INSERM u1003) in 2014 to study the protein interactions between the plasma membrane and the RE (or mitochondrial) by means of cationic colloidal silica cell surface proteome analysis (prostate cancer cells).
Anna Rita Cantelmo, PhD
Anna Rita Cantelmo obtained her PhD in Cellular and Molecular Biology in 2010 at the University of Insubria, Italy. She then moved to Belgium to perform her postdoctoral studies on metabolism and vascular biology at VIB-KU Leuven Center for Cancer Biology (CCB), University of Leuven. During her research activity, she gained expertise in tumor angiogenesis, cellular metabolism and cancer biology. She joined the lab as young group leader to investigate the role of ion channels in regulating tumor vascular barrier abnormalities and metastatic dissemination.
Dmitri Gordienko, PhD
Dr. Dmytro (Dmitri) Gordienko has graduated from Kiev State University in 1986 (MSc in biophysics) and obtained his PhD in biophysics in 1989 at Bogomoletz Institute of Physiology in Kiev Ukraine. He worked as Postdoctoral Fellow in USA (1991-1993: State University of New York at Stony Brook) and in United Kingdom (1995-2000; St. George’s Hospital Medical School at University of London), and then as Senior Lecturer in Pharmacology at St. Georg’es University of London (2000-2011). Starting from 2005 he became a director of laboratory of Molecular pharmacology and biophysics of cell signalling at Bogomoletz Institute of Physiology, and for the period 2011-2016 worked as associate professor at Lille 1 University. Beginning from November 2016 he is employed as Ingénieur de Research at Inserm U1003. The results of his work in the field of physiology, pharmacology and biophysics of smooth muscles, cell signalling systems in cancer, nociception and hypertension, published in 61 scientific papers in peer-reviewed journals, are well internationally recognized (h-index 25, i10-index 38). He was principal investigator on the grants from the Wellcome Trust (Refs: 060659, 064786 and 075112), British Heart Foundation (Ref: PG/08/062/25382) and State Fund for Fundamental Research (Ref: F 46.2/001). In 2004 he has obtained the university title equivalent to HDR in France. His achievements in experimental research were recognized by attribution of the Wellcome Trust Award of Excellence (1999) and State Prize of Ukraine in Science and Technology (2013). He supervised and co-supervised 8 PhD students. His experimental research is focused on the development of innovative experimental strategies to study the dynamics of cellular signaling events using confocal microscopy and patch-clamp.
Loic Lemonnier, PhD
Loïc Lemonnier obtained his PhD in Biology from the University of Lille 1 (France) in June 2004. During his PhD, he studied the involvement of VRACs (Volume-Regulated Anion Channels) in prostate cancer progression under the supervision of Pr. Roman Skryma. After a postdoctoral fellowship in Dr. JW Putney lab (NIEHS, North Carolina, USA), he was recruited as an Inserm researcher (CR) in 2008. His research activity is now focused on TRP and SOC calcium channels and their role in prostate cancer.
Fabien Vanden-Abeele, PhD
Alessandra Fiorio Pla, PhD
Associate Professor in Physiology
Dept. Life Sciences and System Biology (DIBIOS)
University of Torino,
My research activity is focused on cell physiology with particular interest for Ca2+ channels characterization and their involvement in angiogenesis and tumor progression by combining calcium imaging and live cell imaging techniques with cell biology. I am mainly interest on the role of TRP channels in the different pathophysiological role in tumor vascularization and particularly in cell migration and tumor invasion.
Yaroslav Shuba, Professor, PhD
Brigitte Mauroy, MD
Jean-Louis Bonnal, MD
Camille Dejos, PhD
Camille obtained a PhD in Molecular & Cellular Biology in 2014 at the University of Poitiers, France. Her PhD thesis focused on the role of Ca2+ signaling in photoreceptor differentiation. After a first postdoc at the University of Alberta, Canada, Camille worked at the Karolinska Institute, Sweden, where she investigated the role of mitochondria in skin wound healing. She joined the team of Dr. Anna Rita Cantelmo in March 2019.
Charlotte Dubois, PhD
Charlotte DUBOIS obtained her PhD in Biological sciences at the University of Lille. During her PhD (sept 2011-december 2014), she conducted 2 projects: (1) the role of ORAI1/3 (ARC) channels during prostate cancer progression and (2) the characterization of Thapsigargin analogues (i.e ASP-8ADT also known as G-202® (Mipsagargin)). Then, she moved to the University of Leuven (Belgium) to join the laboratory of Pr Peter CARMELIET (Laboratory of vascular biology CCB, VIB KULeuven) to study the metabolism of endothelial cells during physiological and pathological angiogenesis. From October 2015 to September 2018 she has depicted a new non-metabolic role of the glutamine synthetase (GLUL) during angiogenesis. She has joined our lab in November 2018 to conduct a project financed by the Fondation de France. Using an oncogram strategy she aims to (1) predict efficiency of (combined) chemotherapies to offer a personalized medicine for each patient (2) identify (calcium dependent) molecular mechanism(s) involved in therapeutic escape of solid cancers (such as prostate).
Valerio Farfariello, PhD
Valerio Farfariello obtained his PhD in Immunological Sciences from the Sapienza University, Rome (Italy) in Mars 2012. During his PhD, he studied the role of Ca2+-permeable channels (TRPV family) in the maturation of thymocytes. In this period, he also studied the role of TRPV channels in the proliferation and malignant phenotype of brain, bladder and prostate cancer cells. Valerio joined our laboratory in January 2014 as a postdoctoral fellow to study the role of Ca2+-permeable channels in senescence and senescence escape occurring during prostate carcinogenesis. He is also responsible of a project dedicated to the comprehension of the mechanisms of chemotherapy resistance caused by the senescent microenvironment with a focus to Ca2+-channels.
Oksana Iamshanova, MS
Oksana Iamshanova has obtained her BSc in Biology in Taras Shevchenko National University of Kyiv (Ukraine) in 2011. During 2011-2013 she was working at Imperial College London (United Kingdom), where she has achieved MRes in Biochemical Research. In the end of 2013 Oksana has joined our laboratory as a PhD student. Her work is mainly concentrated on studying the role of NALCN in prostate cancer disease.
Kateryna Kondratska, PhD
Kateryna received her Master degree in Applied Physics (Physics of living systems) from the Institute of Physics and Technology, Ukraine in 2005. Kateryna joined our lab in 2011 as a trainee in cell physiology and in 2012 she started her PhD study in the framework of IonTrac project. During her PhD, she was studying the role of calcium-permeable channels in prostate ductal adenocarcinoma resistance to chemotherapy treatments. Kateryna obtained her PhD in Biology in 2015 and now she continues her studies on pancreatic cancer as a postdoc in our lab.
Alexandre Bokhobza, MS
Alexandre Bokhobza obtained his master degree Biologie et santé from EDBSL (Ecole Doctorale Biologie et Santé Lille 1, Lille2), in June 2011. Alexandre joined our laboratory in September 2011 (Titularisation December 2013).
Aurelien Haustrate, MS
Lina Mesilmany, MS
Lina received her master degree in Immunology from the Lebanese University in July 2018. She joined our lab in November 2018 to study the role calcium-permeable channels in senescence during prostate carcinogenesis, as PhD student in co-tutelle with the Lebanese University.
Mathilde Lebas, MS
Mathilde obtained her Master Degree from the University of Lille in 2018 and she now works as Development Engineer in the team of Dr. Annarita Cantelmo.
Manon Clarisse, MS
Manon obtained her master degree in Biology and Health from the University of Lille in 2018. She did some internship during her studies in a lab working on diabetes. More precisely she worked on the development of a new animal model to study the changes in glucose homeostasis after bariatric surgery. She joined our lab in January 2019 as assistant engineer in the team of Dr. Dimitra Gkika working on the implication and regulation of TRPM8 channel in prostate cancer.
Nathalie Ziental Gelus
Laurent Allart obtained his BTS in Biotechnology in 1995. He also holds a Diploma in "Animal Surgery" as well as "Habilitation à l' Expérimentation Animale de niveau 2". Before coming to our lab, Laurent was working in the laboratory U446 (INSERM, Lyon) as well as in Pr. M. Capron's laboratory U449 (INSERM, Lille). In November 2012 Laurent joined our laboratory and he is mainly doing molecular biology experiments. He is also a member of several INSERM Committees, including CSS, CSHSCT and CLAS Inserm.
Emilie obtained her licence degree (BTS) in Biotechnology from the Lycée Valentine Labbé in 2008. She joined our laboratory as a lab technician in February 2014.
Andrée takes care of our lab cleanliness and ensures tidy and healthy working environment for all the members of the lab.
Pauline Jezraoui, MS
Pauline obtained her master degree in health management from the Lille Institute of Health Engineering (ILIS) in 2015. She joined our laboratory as a lab manager in November 2015.