Our publications

2017

Ritaine A, Shapovalov G, Prevarskaya N. Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion. Adv Exp Med Biol. 2017;993:623-637. doi: 10.1007/978-3-319-57732-6_31.  PubMed

Nielsen N, Kondratska K, Ruck T, Hild B, Kovalenko I, Schimmelpfennig S, Welzig J, Sargin S, Lindemann O, Christian S, Meuth SG, Prevarskaya N, Schwab A. TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia. Pflugers Arch. 2017 Aug 28. doi: 10.1007/s00424-017-2057-0.  PubMed

Fliniaux I, Germain E, Farfariello V, Prevarskaya N. TRPs and Ca2+ in cell death and survival. Cell Calcium. 2017 Jul 15. pii: S0143-4160(17)30081-7. doi: 10.1016/j.ceca.2017.07.002.  PubMed

Genova T, Grolez GP, Camillo C, Bernardini M, Bokhobza A, Richard E, Scianna M, Lemonnier L, Valdembri D, Munaron L, Philips MR, Mattot V, Serini G, Prevarskaya N, Gkika D, Pla AF. TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1.J Cell Biol. 2017 May 26. pii: jcb.201506024. doi: 10.1083/jcb.201506024.  PubMed

Monteith GR, Prevarskaya N, Roberts-Thomson SJ. The calcium-cancer signalling nexus. Nat Rev Cancer. 2017 Jun;17(6):367-380. doi: 10.1038/nrc.2017.18.  PubMed

Iamshanova O, Fiorio Pla A, Prevarskaya N. Molecular mechanisms of tumor invasion: regulation by calcium signals. J Physiol. 2017 Mar 17. doi: 10.1113/JP272844.  PubMed

Vancauwenberghe E, Noyer L, Derouiche S, Lemonnier L, Gosset P, Sadofsky LR, Mariot P, Warnier M, Bokhobza A, Slomianny C, Mauroy B, Bonnal JL, Dewailly E, Delcourt P, Allart L, Prevarskaya N, Roudbaraki M. Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Mol Carcinog. 2017 Mar 9. doi: 10.1002/mc.22642. PubMed

Derouiche S, Mariot P, Warnier M, Vancauwenberghe E, Bidaux G, Gosset P, Mauroy B, Bonnal JL, Slomianny C, Delcourt P, Dewailly E, Prevarskaya N, Roudbaraki M. Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells. Cancer Prev Res (Phila). 2017 Jan 17. doi: 10.1158/1940-6207.CAPR-16-0257. PubMed

 

 

2016

Iamshanova O, Mariot P, Lehen'kyi V, Prevarskaya N. Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines. Eur Biophys J. 2016 Oct;45(7):765-777. PubMed PMID: 27660079; PubMed Central PMCID: PMC5045488.

Ivanova H, Ritaine A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G. The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition. Oncotarget. 2016 Aug 2:55704-55720. doi: 10.18632/oncotarget.11005. PubMed PMID: 27494888.

Grolez GP, Gkika D. TRPM8 Puts the Chill on Prostate Cancer.  Pharmaceuticals (Basel). 2016 Jul 9;9(3). pii: E44. doi: 10.3390/ph9030044. Review. PMID: 27409624

Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, Jégou B, Prevarskaya N, Bidaux G. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. FASEB J. 2016 Sep;30(9):3155-70. doi: 10.1096/fj.201600257R. PubMed PMID: 27317670; PubMed Central PMCID: PMC5001517.

Bidaux G, Borowiec AS, Dubois C, Delcourt P, Schulz C, Vanden Abeele F, Lepage G, Desruelles E, Bokhobza A, Dewailly E, Slomianny C, Roudbaraki M, Héliot L, Bonnal JL, Mauroy B, Mariot P, Lemonnier L, Prevarskaya N. Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Oncotarget. 2016 May 17;7(20):29063-80. doi: 10.18632/oncotarget.8666. PubMed PMID: 27074561; PubMed Central PMCID: PMC5045378.

Bidaux G, Borowiec AS, Prevarskaya N, Gordienko D. Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate. Channels (Austin). 2016 Jul 3;10(4):320-31. doi: 10.1080/19336950.2016.1168551. PubMed PMID: 27014839; PubMed Central PMCID: PMC4954583.

Philyppov IB, Paduraru ON, Gulak KL, Skryma R, Prevarskaya N, Shuba YM. TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats.  Smooth Muscle Res. 2016;52:1-17. doi:10.1540/jsmr.52.1. PubMed PMID: 26935999.

Shapovalov G, Ritaine A, Skryma R, Prevarskaya N. Role of TRP ion channels in cancer and tumorigenesis. Semin Immunopathol. 2016 May;38(3):357-69. doi:10.1007/s00281-015-0525-1. Review. PubMed PMID: 26842901.

Fiorio Pla A, Kondratska K, Prevarskaya N. STIM and ORAI proteins: crucial roles in hallmarks of cancer. Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C509-19. doi: 10.1152/ajpcell.00364.2015. Review. PubMed PMID: 26791491.

 

 

2015

Bernardini M, Fiorio Pla A, Prevarskaya N, Gkika D. Human transient receptor potential (TRP) channel expression profiling in carcinogenesis. Int J Dev Biol. 2015;59(7-9):399-406. doi: 10.1387/ijdb.150232dg. Review. PubMed PMID: 26679952.

Dubois C, Prevarskaya N, Vanden Abeele F. The calcium-signaling toolkit: Updates needed. Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1337-43. doi: 10.1016/j.bbamcr.2015.11.033. Review. PubMed PMID: 26658643.

Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N. Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3345-54. doi: 10.1073/pnas.1423357112. PubMed PMID: 26080404; PubMed  Central PMCID: PMC4491737.

Smani T, Shapovalov G, Skryma R, Prevarskaya N, Rosado JA. Functional and physiopathological implications of TRP channels. Biochim Biophys Acta. 2015 Aug;1853(8):1772-82. doi: 10.1016/j.bbamcr.2015.04.016. Review. PubMed PMID: 25937071.

Dubois C, Vanden Abeele F, Prevarskaya N. [A new oncogenic switch in prostate cancer progression: the exceptional ORAI3]. Med Sci (Paris). 2015 Mar;31(3):244-7. doi: 10.1051/medsci/20153103006. French. PubMed PMID: 25855274.

Vanden Abeele F, Dubois C, Shuba Y, Prevarskaya N. Disrupting the dynamic equilibrium of ORAI channels determines the phenotype of malignant cells. Mol Cell Oncol. 2015 Jan 21;2(2):e975631. doi: 10.4161/23723556.2014.975631. PubMed PMID: 27308432; PubMed Central PMCID: PMC4904888.

Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N. Calcium homeostasis in cancer: A focus on senescence. Biochim Biophys Acta. 2015 Sep;1853(9):1974-9. doi: 10.1016/j.bbamcr.2015.03.005. Review. PubMed PMID:25764980.

Warnier M, Roudbaraki M, Derouiche S, Delcourt P, Bokhobza A, Prevarskaya N, Mariot P. CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis. Oncogene. 2015 Oct 16;34(42):5383-94. doi: 10.1038/onc.2014.467. PubMed PMID: 25619833.

Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, Bokhobza A, Bidaux G, Degerny C, Verreman K, Guarmit B, Benahmed M, de Launoit Y, Bindels RJ, Fiorio Pla A, Prevarskaya N. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol. 2015 Jan 5;208(1):89-107. doi: 10.1083/jcb.201402076. PubMed PMID: 25559186; PubMed Central PMCID: PMC4284226.

Gordienko D, Povstyan O, Sukhanova K, Raphaël M, Harhun M, Dyskina Y, Lehen'kyi V, Jama A, Lu ZL, Skryma R, Prevarskaya N. Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension. Cardiovasc Res. 2015 Feb 1;105(2):131-42. doi: 10.1093/cvr/cvu249. PubMed PMID: 25514930.

Fiorio Pla A, Brossa A, Bernardini M, Genova T, Grolez G, Villers A, Leroy X, Prevarskaya N, Gkika D, Bussolati B. Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib. BMC Cancer. 2014 Dec 12;14:939. doi: 10.1186/1471-2407-14-939. PubMed PMID: 25494980; PubMed Central PMCID: PMC4295225.

Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N. Ion channels in the regulation of apoptosis. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2532-46. doi: 10.1016/j.bbamem.2014.10.030. Review. PubMed PMID: 25450339.

 

2014

Raphaël M, Lehen'kyi V, Vandenberghe M, Beck B, Khalimonchyk S, Vanden Abeele F, Farsetti L, Germain E, Bokhobza A, Mihalache A, Gosset P, Romanin C, Clézardin P, Skryma R, Prevarskaya N. TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3870-9. doi: 10.1073/pnas.1413409111. PubMed PMID: 25172921; PubMed Central PMCID: PMC4169956.

Dubois C, Vanden Abeele F, Lehen'kyi V, Gkika D, Guarmit B, Lepage G, Slomianny C, Borowiec AS, Bidaux G, Benahmed M, Shuba Y, Prevarskaya N. Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer. Cancer Cell. 2014 Jul 14;26(1):19-32. doi: 10.1016/j.ccr.2014.04.025. PubMed PMID: 24954132.

Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun. 2014 May 6;5:3792. doi: 10.1038/ncomms4792. PubMed PMID: 24797322.

Kondratskyi A, Yassine M, Slomianny C, Kondratska K, Gordienko D, Dewailly E, Lehen'kyi V, Skryma R, Prevarskaya N. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 2014 Apr 24;5:e1193.
doi: 10.1038/cddis.2014.156. PubMed PMID: 24763050; PubMed Central PMCID:PMC4001310.

Kondratska K, Kondratskyi A, Yassine M, Lemonnier L, Lepage G, Morabito A, Skryma R, Prevarskaya N. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma. Biochim Biophys Acta. 2014 Oct;1843(10):2263-9. doi: 10.1016/j.bbamcr.2014.02.012. PubMed PMID: 24583265.

Prevarskaya N, Ouadid-Ahidouch H, Skryma R, Shuba Y. Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks? Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130097. doi: 10.1098/rstb.2013.0097. Review. PubMed PMID: 24493745; PubMed Central PMCID: PMC3917351.

 

2013

Vandenberghe M, Raphaël M, Lehen'kyi V, Gordienko D, Hastie R, Oddos T, Rao A, Hogan PG, Skryma R, Prevarskaya N. ORAI1 calcium channel orchestrates skin homeostasis. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4839-48. doi:10.1073/pnas.1310394110. PubMed PMID: 24277812; PubMed Central PMCID: PMC3864283.

Gackière F, Warnier M, Katsogiannou M, Derouiche S, Delcourt P, Dewailly E, Slomianny C, Humez S, Prevarskaya N, Roudbaraki M, Mariot P. Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium
channels participates in prostate cancer cell growth. Biol Open. 2013 Jul 26;2(9):941-51. doi: 10.1242/bio.20135215. PubMed PMID: 24143281; PubMed Central PMCID: PMC3773341.

Kondratskyi A, Yassine M, Kondratska K, Skryma R, Slomianny C, Prevarskaya N. Calcium-permeable ion channels in control of autophagy and cancer. Front Physiol. 2013 Oct 2;4:272. doi: 10.3389/fphys.2013.00272. PubMed PMID: 24106480; PubMed Central PMCID: PMC3788328.

Vanden Abeele F, Kondratskyi A, Dubois C, Shapovalov G, Gkika D, Busserolles J, Shuba Y, Skryma R, Prevarskaya N. Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia. J Cell Sci. 2013 Oct 1;126(Pt 19):4479-89. doi: 10.1242/jcs.131631. PubMed PMID: 23943870.

Dubois C, Vanden Abeele F, Sehgal P, Olesen C, Junker S, Christensen SB, Prevarskaya N, Møller JV. Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium. FEBS J. 2013 Nov;280(21):5430-40. doi: 10.1111/febs.12475. PubMed PMID: 23927406.

Shapovalov G, Gkika D, Devilliers M, Kondratskyi A, Gordienko D, Busserolles J, Bokhobza A, Eschalier A, Skryma R, Prevarskaya N. Opiates modulate thermosensation by internalizing cold receptor TRPM8. Cell Rep. 2013 Aug 15;4(3):504-15. doi: 10.1016/j.celrep.2013.07.002. PubMed PMID: 23911290.

Oulidi A, Bokhobza A, Gkika D, Vanden Abeele F, Lehen'kyi V, Ouafik L, Mauroy B, Prevarskaya N. TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion. PLoS One. 2013 May
31;8(5):e64885. doi: 10.1371/journal.pone.0064885. PubMed PMID: 23741410; PubMed Central PMCID: PMC3669125.

Dubois C, Vanden Abeele F, Prevarskaya N. Targeting apoptosis by the remodelling of calcium-transporting proteins in cancerogenesis. FEBS J. 2013 Nov;280(21):5500-10. doi: 10.1111/febs.12246. Review. PubMed PMID: 23497199.

 

Fioro Pla A and Gkika D. Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis. Front. Physiol. 2013 Nov 5;4:311. doi: 10.3389/fphys.2013.00311. PMID: 24204345

Derouiche S, Warnier M, Mariot P, Gosset P, Mauroy B, Bonnal JL, Slomianny C, Delcourt P, Prevarskaya N, Roudbaraki M. Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling. Springerplus. 2013
Dec;2(1):54. doi: 10.1186/2193-1801-2-54. PubMed PMID: 23450760; PubMed Central PMCID: PMC3581770.

Hammadi M, Oulidi A, Gackière F, Katsogiannou M, Slomianny C, Roudbaraki M, Dewailly E, Delcourt P, Lepage G, Lotteau S, Ducreux S, Prevarskaya N, Van Coppenolle F. Modulation of ER stress and apoptosis by endoplasmic reticulum
calcium leak via translocon during unfolded protein response: involvement of GRP78. FASEB J. 2013 Apr;27(4):1600-9. doi: 10.1096/fj.12-218875. PubMed PMID: 23322163.

Prevarskaya N, Skryma R, Shuba Y. Targeting Ca²⁺ transport in cancer: close reality or long perspective? Expert Opin Ther Targets. 2013 Mar;17(3):225-41. doi: 10.1517/14728222.2013.741594. Review. PubMed PMID: 23294334.

Vanoverberghe K, Lehen'kyi V, Thébault S, Raphaël M, Vanden Abeele F, Slomianny C, Mariot P, Prevarskaya N. Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells. PLoS One. 2012;7(9):e45615. doi:10.1371/journal.pone.0045615. PubMed PMID: 23049826; PubMed Central PMCID: PMC3458093.

Shapovalov G, Skryma R, Prevarskaya N. Calcium channels and prostate cancer. Recent Pat Anticancer Drug Discov. 2013 Jan 1;8(1):18-26. Review. PubMed PMID:22694290.

 

2012

 

Lehen'kyi V, Raphaël M, Prevarskaya N. The role of the TRPV6 channel in cancer. J Physiol. 2012 Mar 15;590(6):1369-76. doi: 10.1113/jphysiol.2011.225862. Review. PubMed PMID: 22331416; PubMed Central PMCID: PMC3382328.

Bidaux G, Beck B, Zholos A, Gordienko D, Lemonnier L, Flourakis M, Roudbaraki M, Borowiec AS, Fernández J, Delcourt P, Lepage G, Shuba Y, Skryma R, Prevarskaya N. Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. J Biol Chem. 2012 Jan 27;287(5):2948-62. doi: 10.1074/jbc.M111.270256. PubMed PMID: 22128173; PubMed Central PMCID: PMC3270952.

Fernández JA, Skryma R, Bidaux G, Magleby KL, Scholfield CN, McGeown JG, Prevarskaya N, Zholos AV. Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors. J Biol Chem. 2012 Jan 27;287(5):2963-70. doi: 10.1074/jbc.M111.272823. PubMed PMID: 22128172; PubMed Central PMCID: PMC3270953.

 

2011

 

Lehen′kyi V, Prevarskaya N. Study of TRP Channels in Cancer Cells. In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 17. PubMed PMID: 22593971.

Firlej V, Mathieu JR, Gilbert C, Lemonnier L, Nakhlé J, Gallou-Kabani C, Guarmit B, Morin A, Prevarskaya N, Delongchamps NB, Cabon F. Thrombospondin-1 triggers cell migration and development of advanced prostate tumors. Cancer Res. 2011 Dec 15;71(24):7649-58. doi: 10.1158/0008-5472.CAN-11-0833. PubMed PMID: 22037878.

Skryma R, Prevarskaya N, Gkika D, Shuba Y. From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. Nat Rev Urol. 2011 Oct 4;8(11):617-30. doi: 10.1038/nrurol.2011.142. Review. PubMed PMID: 21971315.

Lehen'kyi V, Shapovalov G, Skryma R, Prevarskaya N. Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis. Am J Physiol Cell Physiol. 2011 Dec;301(6):C1281-9. doi: 10.1152/ajpcell.00249.2011. Review. PubMed PMID: 21940667.

Prevarskaya N, Skryma R, Shuba Y. Calcium in tumour metastasis: new roles for known actors. Nat Rev Cancer. 2011 Jul 22;11(8):609-18. doi: 10.1038/nrc3105. Review. PubMed PMID: 21779011.

Shapovalov G, Lehen'kyi V, Skryma R, Prevarskaya N. TRP channels in cell survival and cell death in normal and transformed cells. Cell Calcium. 2011 Sep;50(3):295-302. doi: 10.1016/j.ceca.2011.05.006. Review. PubMed PMID: 21628069.

Gkika D, Prevarskaya N. TRP channels in prostate cancer: the good, the bad and the ugly? Asian J Androl. 2011 Sep;13(5):673-6. doi: 10.1038/aja.2011.18. PubMed PMID: 21623387; PubMed Central PMCID: PMC3739589.

Lehen'kyi V, Raphaël M, Oulidi A, Flourakis M, Khalimonchyk S, Kondratskyi A, Gordienko DV, Mauroy B, Bonnal JL, Skryma R, Prevarskaya N. TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth. PLoS One. 2011 Feb 11;6(2):e16856. doi: 10.1371/journal.pone.0016856. PubMed PMID: 21347289; PubMed Central PMCID: PMC3037935.

Lehen'kyi V, Prevarskaya N. Oncogenic TRP channels. Adv Exp Med Biol. 2011;704:929-45. doi: 10.1007/978-94-007-0265-3_48. Review. PubMed PMID: 21290334.

Fernández JA, Skryma R, Bidaux G, Magleby KL, Scholfield CN, McGeown JG, Prevarskaya N, Zholos AV. Voltage- and cold-dependent gating of single TRPM8 ion channels. J Gen Physiol. 2011 Feb;137(2):173-95. doi: 10.1085/jgp.201010498.
PubMed PMID: 21282398; PubMed Central PMCID: PMC3032375.

Bavencoffe A, Kondratskyi A, Gkika D, Mauroy B, Shuba Y, Prevarskaya N, Skryma R. Complex regulation of the TRPM8 cold receptor channel: role of arachidonic acid release following M3 muscarinic receptor stimulation. J Biol Chem. 2011 Mar 18;286(11):9849-55. doi: 10.1074/jbc.M110.162016. PubMed PMID: 21245133; PubMed Central PMCID: PMC3059061.

Lehen'kyi V, Vandenberghe M, Belaubre F, Julié S, Castex-Rizzi N, Skryma R, Prevarskaya N. Acceleration of keratinocyte differentiation by transient receptor potential vanilloid (TRPV6) channel activation. J Eur Acad Dermatol Venereol. 2011 Feb;25 Suppl 1:12-8. doi: 10.1111/j.1468-3083.2010.03894.x. PubMed PMID: 21175869.

 

2010

 

Flourakis M, Lehen'kyi V, Beck B, Raphaël M, Vandenberghe M, Abeele FV, Roudbaraki M, Lepage G, Mauroy B, Romanin C, Shuba Y, Skryma R, Prevarskaya N. Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells. Cell Death Dis. 2010 Sep 16;1:e75. doi: 10.1038/cddis.2010.52. PubMed PMID: 21364678; PubMed Central PMCID: PMC3032347.

Gkika D, Flourakis M, Lemonnier L, Prevarskaya N. PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression. Oncogene. 2010 Aug 12;29(32):4611-6. doi: 10.1038/onc.2010.210. PubMed PMID:
20531306.

El Boustany C, Katsogiannou M, Delcourt P, Dewailly E, Prevarskaya N, Borowiec AS, Capiod T. Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells. Cell Calcium. 2010 Apr;47(4):350-9. doi: 10.1016/j.ceca.2010.01.006. PubMed PMID: 20172609.

Prevarskaya N, Skryma R, Shuba Y. Ion channels and the hallmarks of cancer. Trends Mol Med. 2010 Mar;16(3):107-21. doi: 10.1016/j.molmed.2010.01.005. Review. PubMed PMID: 20167536.

 

Bavencoffe A, Gkika D, Kondratskyi A, Beck B, Borowiec AS, Bidaux G, Busserolles J, Eschalier A, Shuba Y, Skryma R, Prevarskaya N. The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway. J Biol Chem. 2010 Mar 26;285(13):9410-9. doi: 10.1074/jbc.M109.069377. PubMed PMID: 20110357; PubMed Central PMCID: PMC2843190.

 

Monet M, Lehen'kyi V, Gackiere F, Firlej V, Vandenberghe M, Roudbaraki M, Gkika D, Pourtier A, Bidaux G, Slomianny C, Delcourt P, Rassendren F, Bergerat JP, Ceraline J, Cabon F, Humez S, Prevarskaya N. Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 2010 Feb 1;70(3):1225-35. doi: 10.1158/0008-5472.CAN-09-2205. PubMed  PMID: 20103638.

 

2009

 

Katsogiannou M, El Boustany C, Gackiere F, Delcourt P, Athias A, Mariot P, Dewailly E, Jouy N, Lamaze C, Bidaux G, Mauroy B, Prevarskaya N, Slomianny C. Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells. PLoS One. 2009 Sep 18;4(9):e7068. doi: 10.1371/journal.pone.0007068. PubMed PMID: 19763272; PubMed Central PMCID: PMC2742726.

 

Flourakis M, Prevarskaya N. Insights into Ca2+ homeostasis of advanced prostate cancer cells. Biochim Biophys Acta. 2009 Jun;1793(6):1105-9. doi: 10.1016/j.bbamcr.2009.01.009. Review. PubMed PMID: 19339216.

 

Lallet-Daher H, Roudbaraki M, Bavencoffe A, Mariot P, Gackière F, Bidaux G, Urbain R, Gosset P, Delcourt P, Fleurisse L, Slomianny C, Dewailly E, Mauroy B, Bonnal JL, Skryma R, Prevarskaya N. Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry. Oncogene. 2009 Apr 16;28(15):1792-806. doi: 10.1038/onc.2009.25. PubMed PMID: 19270724.

 

Gkika D, Prevarskaya N. Molecular mechanisms of TRP regulation in tumor growth and metastasis. Biochim Biophys Acta. 2009 Jun;1793(6):953-8. doi: 10.1016/j.bbamcr.2008.11.010. Review. PubMed PMID: 19103233.

 

2008

 

El Boustany C, Bidaux G, Enfissi A, Delcourt P, Prevarskaya N, Capiod T. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology. 2008 Jun;47(6):2068-77. doi: 10.1002/hep.22263. PubMed PMID: 18506892.

 

Gackière F, Bidaux G, Delcourt P, Van Coppenolle F, Katsogiannou M, Dewailly  E, Bavencoffe A, Van Chuoï-Mariot MT, Mauroy B, Prevarskaya N, Mariot P. CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells. J Biol Chem. 2008 Apr 11;283(15):10162-73.  doi: 10.1074/jbc.M707159200. Erratum in: J Biol Chem. 2008 Jul 11;283(28):19872.  PubMed PMID: 18230611.

 

Beck B, Lehen'kyi V, Roudbaraki M, Flourakis M, Charveron M, Bordat P, Polakowska R, Prevarskaya N, Skryma R. TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma. Cell Calcium. 2008 May;43(5):492-505. PubMed PMID: 17920677.

 

2007

 

Capiod T, Shuba Y, Skryma R, Prevarskaya N. Calcium signalling and cancer cell growth. Subcell Biochem. 2007;45:405-27. Review. PubMed PMID: 18193646.

 

Prevarskaya N, Zhang L, Barritt G. TRP channels in cancer. Biochim Biophys Acta. 2007 Aug;1772(8):937-46. Review. PubMed PMID: 17616360.

 

Lehen'kyi V, Beck B, Polakowska R, Charveron M, Bordat P, Skryma R, Prevarskaya N. TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes. J Biol Chem. 2007 Aug 3;282(31):22582-91. PubMed PMID: 17550901.

 

Lehen'kyi V, Flourakis M, Skryma R, Prevarskaya N. TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways. Oncogene.  2007 Nov 15;26(52):7380-5. PubMed PMID: 17533368.

 

Bidaux G, Flourakis M, Thebault S, Zholos A, Beck B, Gkika D, Roudbaraki M, Bonnal JL, Mauroy B, Shuba Y, Skryma R, Prevarskaya N. Prostate cell differentiation status determines transient receptor potential melastatin member  8 channel subcellular localization and function. J Clin Invest. 2007 Jun;117(6):1647-57. PubMed PMID: 17510704; PubMed Central PMCID: PMC1866249.

 

Prevarskaya N, Skryma R, Bidaux G, Flourakis M, Shuba Y. Ion channels in death and differentiation of prostate cancer cells. Cell Death Differ. 2007 Jul;14(7):1295-304. Review. PubMed PMID: 17479110.

 

Prevarskaya N, Flourakis M, Bidaux G, Thebault S, Skryma R. Differential role of TRP channels in prostate cancer. Biochem Soc Trans. 2007 Feb;35(Pt 1):133-5. Review. PubMed PMID: 17233619.

 

Crépin A, Bidaux G, Vanden-Abeele F, Dewailly E, Goffin V, Prevarskaya N, Slomianny C. Prolactin stimulates prostate cell proliferation by increasing endoplasmic reticulum content due to SERCA 2b over-expression. Biochem J. 2007 Jan 1;401(1):49-55. PubMed PMID: 16965263; PubMed Central PMCID: PMC1698681.

 

Beck B, Bidaux G, Bavencoffe A, Lemonnier L, Thebault S, Shuba Y, Barrit G, Skryma R, Prevarskaya N. Prospects for prostate cancer imaging and therapy using  high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41(3):285-94. PubMed PMID: 16949669.

 

2006

 

Vanden Abeele F, Zholos A, Bidaux G, Shuba Y, Thebault S, Beck B, Flourakis M, Panchin Y, Skryma R, Prevarskaya N. Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. J Biol Chem. 2006 Dec 29;281(52):40174-82. PubMed PMID: 17082190.

 

Vanden Abeele F, Bidaux G, Gordienko D, Beck B, Panchin YV, Baranova AV, Ivanov DV, Skryma R, Prevarskaya N. Functional implications of calcium permeability of the channel formed by pannexin 1. J Cell Biol. 2006 Aug 14;174(4):535-46. Erratum in: J Cell Biol. 2013 May 27;201(5):777. PubMed PMID: 16908669; PubMed Central PMCID: PMC2064259.

 

Beck B, Zholos A, Sydorenko V, Roudbaraki M, Lehen'kyi V, Bordat P, Prevarskaya N, Skryma R. TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes. J Invest Dermatol. 2006 Sep;126(9):1982-93. PubMed PMID: 16741513.

 

Flourakis M, Van Coppenolle F, Lehen'kyi V, Beck B, Skryma R, Prevarskaya N.  Passive calcium leak via translocon is a first step for iPLA2-pathway regulated store operated channels activation. FASEB J. 2006 Jun;20(8):1215-7. PubMed PMID:  16611832.

 

Humez S, Monet M, Legrand G, Lepage G, Delcourt P, Prevarskaya N. Epidermal growth factor-induced neuroendocrine differentiation and apoptotic resistance of  androgen-independent human prostate cancer cells. Endocr Relat Cancer. 2006 Mar;13(1):181-95. PubMed PMID: 16601287.

 

Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen'kyi V, Slomianny C, Beck B, Mariot P, Bonnal JL, Mauroy B, Shuba Y, Capiod  T, Skryma R, Prevarskaya N. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res. 2006 Feb 15;66(4):2038-47. PubMed PMID: 16489003.

 

Gackière F, Bidaux G, Lory P, Prevarskaya N, Mariot P. A role for voltage gated T-type calcium channels in mediating "capacitative" calcium entry? Cell Calcium. 2006 Apr;39(4):357-66. PubMed PMID: 16442617.

 

2005

 

Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, Roudbaraki M, Delcourt P, Panchin Y, Shuba Y, Skryma R, Prevarskaya N. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member  8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J Biol Chem. 2005 Nov 25;280(47):39423-35. PubMed PMID:  16174775.

 

Bidaux G, Roudbaraki M, Merle C, Crépin A, Delcourt P, Slomianny C, Thebault  S, Bonnal JL, Benahmed M, Cabon F, Mauroy B, Prevarskaya N. Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocr Relat Cancer. 2005 Jun;12(2):367-82. PubMed PMID: 15947109.

 

Lemonnier L, Lazarenko R, Shuba Y, Thebault S, Roudbaraki M, Lepage G, Prevarskaya N, Skryma R. Alterations in the regulatory volume decrease (RVD) and  swelling-activated Cl- current associated with neuroendocrine differentiation of  prostate cancer epithelial cells. Endocr Relat Cancer. 2005 Jun;12(2):335-49. PubMed PMID: 15947107.

 

Thebault S, Zholos A, Enfissi A, Slomianny C, Dewailly E, Roudbaraki M, Parys J, Prevarskaya N. Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line. J Cell Physiol. 2005 Jul;204(1):320-8. PubMed PMID: 15672411.

 

Zholos A, Beck B, Sydorenko V, Lemonnier L, Bordat P, Prevarskaya N, Skryma R. Ca(2+)- and volume-sensitive chloride currents are differentially regulated by agonists and store-operated Ca2+ entry. J Gen Physiol. 2005 Feb;125(2):197-211. PubMed PMID: 15657298; PubMed Central PMCID: PMC2217498.

 

2004

 

Humez S, Monet M, van Coppenolle F, Delcourt P, Prevarskaya N. The role of intracellular pH in cell growth arrest induced by ATP. Am J Physiol Cell Physiol. 2004 Dec;287(6):C1733-46. PubMed PMID: 15355852.

 

Prevarskaya N, Skryma R, Shuba Y. Ca2+ homeostasis in apoptotic resistance of prostate cancer cells. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1326-35. Review. PubMed PMID: 15336979.

 

Humez S, Legrand G, Vanden-Abeele F, Monet M, Marchetti P, Lepage G, Crepin A, Dewailly E, Wuytack F, Prevarskaya N. Role of endoplasmic reticulum calcium content in prostate cancer cell growth regulation by IGF and TNFalpha. J Cell Physiol. 2004 Nov;201(2):201-13. PubMed PMID: 15334655.

 

Van Coppenolle F, Vanden Abeele F, Slomianny C, Flourakis M, Hesketh J, Dewailly E, Prevarskaya N. Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores. J Cell Sci. 2004 Aug 15;117(Pt 18):4135-42. PubMed PMID: 15280427.

 

Lemonnier L, Shuba Y, Crepin A, Roudbaraki M, Slomianny C, Mauroy B, Nilius B, Prevarskaya N, Skryma R. Bcl-2-dependent modulation of swelling-activated Cl-  current and ClC-3 expression in human prostate cancer epithelial cells. Cancer Res. 2004 Jul 15;64(14):4841-8. PubMed PMID: 15256454.

 

Vanden Abeele F, Lemonnier L, Thébault S, Lepage G, Parys JB, Shuba Y, Skryma R, Prevarskaya N. Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells. J Biol Chem. 2004 Jul 16;279(29):30326-37. PubMed PMID: 15138280.

 

Ouadid-Ahidouch H, Roudbaraki M, Ahidouch A, Delcourt P, Prevarskaya N. Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells. Biochem Biophys Res Commun. 2004 Mar 26;316(1):244-51. PubMed PMID: 15003537.

 

Ouadid-Ahidouch H, Roudbaraki M, Delcourt P, Ahidouch A, Joury N, Prevarskaya N. Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol. 2004 Jul;287(1):C125-34. PubMed PMID: 14985237.

 

Lemonnier L, Prevarskaya N, Mazurier J, Shuba Y, Skryma R. 2-APB inhibits volume-regulated anion channels independently from intracellular calcium signaling modulation. FEBS Lett. 2004 Jan 2;556(1-3):121-6. PubMed PMID: 14706838.

 

Vanoverberghe K, Vanden Abeele F, Mariot P, Lepage G, Roudbaraki M, Bonnal JL, Mauroy B, Shuba Y, Skryma R, Prevarskaya N. Ca2+ homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cells. Cell Death Differ. 2004 Mar;11(3):321-30. PubMed PMID: 14685164.

 

Van Coppenolle F, Skryma R, Ouadid-Ahidouch H, Slomianny C, Roudbaraki M, Delcourt P, Dewailly E, Humez S, Crépin A, Gourdou I, Djiane J, Bonnal JL, Mauroy B, Prevarskaya N. Prolactin stimulates cell proliferation through a long form of  prolactin receptor and K+ channel activation. Biochem J. 2004 Feb 1;377(Pt 3):569-78. PubMed PMID: 14565846; PubMed Central PMCID: PMC1223902.

 

2003

 

Thebault S, Roudbaraki M, Sydorenko V, Shuba Y, Lemonnier L, Slomianny C, Dewailly E, Bonnal JL, Mauroy B, Skryma R, Prevarskaya N. Alpha1-adrenergic receptors activate Ca(2+)-permeable cationic channels in prostate cancer epithelial cells. J Clin Invest. 2003 Jun;111(11):1691-701. PubMed PMID: 12782672; PubMed Central PMCID: PMC156103.

 

Vanoverberghe K, Mariot P, Vanden Abeele F, Delcourt P, Parys JB, Prevarskaya N. Mechanisms of ATP-induced calcium signaling and growth arrest in human prostate cancer cells. Cell Calcium. 2003 Jul;34(1):75-85. PubMed PMID: 12767895.

 

Vanden Abeele F, Shuba Y, Roudbaraki M, Lemonnier L, Vanoverberghe K, Mariot P, Skryma R, Prevarskaya N. Store-operated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis. Cell Calcium. 2003 May-Jun;33(5-6):357-73. PubMed PMID: 12765682.

 

Sydorenko V, Shuba Y, Thebault S, Roudbaraki M, Lepage G, Prevarskaya N, Skryma R. Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells. J Physiol. 2003 May 1;548(Pt 3):823-36. PubMed PMID: 12724346; PubMed Central PMCID: PMC2342876.

 

Ivanov DV, Tyazhelova TV, Lemonnier L, Kononenko N, Pestova AA, Nikitin EA,  Prevarskaya N, Skryma R, Panchin YV, Yankovsky NK, Baranova AV. A new human gene  KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. FEBS Lett. 2003 Mar 27;539(1-3):156-60. PubMed PMID: 12650944.

 

Vanden Abeele F, Roudbaraki M, Shuba Y, Skryma R, Prevarskaya N. Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1. J Biol Chem. 2003 Apr 25;278(17):15381-9. PubMed PMID: 12584203.

 

2002

 

Debarbieux-Deleporte M, Delbreil B, Collin T, Delcourt P, Vasseur J, Prevarskaya N, Ouadid-Ahidouch H. InsP(3)-mediated calcium release induced by heterologous expression of total chicory Leaf RNA. Biol Cell. 2002 Nov;94(7-8):545-52. PubMed PMID: 12566227.

 

Vitko YV, Pogorelaya NH, Prevarskaya N, Skryma R, Shuba YM. Proteolytic modification of swelling-activated Cl- current in LNCaP prostate cancer epithelial cells. J Bioenerg Biomembr. 2002 Aug;34(4):307-15. PubMed PMID: 12392194.

 

Vanden Abeele F, Skryma R, Shuba Y, Van Coppenolle F, Slomianny C, Roudbaraki M, Mauroy B, Wuytack F, Prevarskaya N. Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells. Cancer Cell. 2002 Mar;1(2):169-79. PubMed PMID: 12086875.

 

Lemonnier L, Vitko Y, Shuba YM, Vanden Abeele F, Prevarskaya N, Skryma R. Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents.  FEBS Lett. 2002 Jun 19;521(1-3):152-6. PubMed PMID: 12067708.

 

Mariot P, Vanoverberghe K, Lalevee N, Rossier MF, Prevarskaya N. Overexpression of an alpha 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells. J Biol Chem. 2002  Mar 29;277(13):10824-33. PubMed PMID: 11799114.

 

Lemonnier L, Prevarskaya N, Shuba Y, Vanden Abeele F, Nilius B, Mazurier J,  Skryma R. Ca2+ modulation of volume-regulated anion channels: evidence for colocalization with store-operated channels. FASEB J. 2002 Feb;16(2):222-4. PubMed PMID: 11744619.

 

2001

 

Ouadid-Ahidouch H, Le Bourhis X, Roudbaraki M, Toillon RA, Delcourt P, Prevarskaya N. Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether.a-gogo K+ channel. Receptors Channels. 2001;7(5):345-56. PubMed PMID: 11697078.

 

Legrand G, Humez S, Slomianny C, Dewailly E, Vanden Abeele F, Mariot P, Wuytack F, Prevarskaya N. Ca2+ pools and cell growth. Evidence for sarcoendoplasmic Ca2+-ATPases 2B involvement in human prostate cancer cell growth control. J Biol Chem. 2001 Dec 14;276(50):47608-14. PubMed PMID: 11606580.

 

Rybalchenko V, Prevarskaya N, Van Coppenolle F, Legrand G, Lemonnier L, Le Bourhis X, Skryma R. Verapamil inhibits proliferation of LNCaP human prostate cancer cells influencing K+ channel gating. Mol Pharmacol. 2001 Jun;59(6):1376-87. PubMed PMID: 11353796.

 

Van Coppenolle F, Slomianny C, Carpentier F, Le Bourhis X, Ahidouch A, Croix D, Legrand G, Dewailly E, Fournier S, Cousse H, Authie D, Raynaud JP, Beauvillain JC, Dupouy JP, Prevarskaya N. Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence. Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E120-9. PubMed PMID: 11120666.

 

2000

 

Ouadid-Ahidouch H, Chaussade F, Roudbaraki M, Slomianny C, Dewailly E, Delcourt P, Prevarskaya N. KV1.1 K(+) channels identification in human breast carcinoma cells: involvement in cell proliferation. Biochem Biophys Res Commun. 2000 Nov 19;278(2):272-7. PubMed PMID: 11097830.

 

Shuba YM, Prevarskaya N, Lemonnier L, Van Coppenolle F, Kostyuk PG, Mauroy B, Skryma R. Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line. Am J Physiol Cell Physiol. 2000 Oct;279(4):C1144-54. PubMed PMID: 11003595.

 

Skryma R, Mariot P, Bourhis XL, Coppenolle FV, Shuba Y, Vanden Abeele F, Legrand G, Humez S, Boilly B, Prevarskaya N. Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis. J Physiol. 2000 Aug 15;527 Pt 1:71-83. PubMed PMID: 10944171; PubMed Central PMCID: PMC2270062.

 

Mariot P, Prevarskaya N, Roudbaraki MM, Le Bourhis X, Van Coppenolle F, Vanoverberghe K, Skryma R. Evidence of functional ryanodine receptor involved in  apoptosis of prostate cancer (LNCaP) cells. Prostate. 2000 May 15;43(3):205-14. PubMed PMID: 10797495.

 

Van Coppenolle F, Le Bourhis X, Carpentier F, Delaby G, Cousse H, Raynaud JP, Dupouy JP, Prevarskaya N. Pharmacological effects of the lipidosterolic extract of Serenoa repens (Permixon) on rat prostate hyperplasia induced by hyperprolactinemia: comparison with finasteride. Prostate. 2000 Apr 1;43(1):49-58. PubMed PMID: 10725865.

 

1999

 

Ouadid-Ahidouch H, Van Coppenolle F, Le Bourhis X, Belhaj A, Prevarskaya N.  Potassium channels in rat prostate epithelial cells. FEBS Lett. 1999 Oct 1;459(1):15-21. PubMed PMID: 10508909.

 

Skryma R, Van Coppenolle F, Dufy-Barbe L, Dufy B, Prevarskaya N. Characterization of Ca(2+)-inhibited potassium channels in the LNCaP human prostate cancer cell line. Receptors Channels. 1999;6(4):241-53. PubMed PMID: 10412718.

 

Debarbieux M, Ouadid-Ahidouch H, Delpierre N, Vasseur J, Prevarskaya N. A calcium homeostasis mechanism induced by heterologous expression of total RNA from chicory leaves in Xenopus oocytes. J Membr Biol. 1999 Jan 1;167(1):25-33. PubMed PMID: 9878072.