News

09.09.2019 - New research article on TRPM8 channels interaction with lipid rafts in prostate cancer. 

Grolez GP, Gordiendko DV, Clarisse M, Hammadi M, Desruelles E, Fromont G, Prevarskaya N, Slomianny C, Gkika D.
TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration.
Cell Death Dis. 2019 Sep 9;10(9):652. 
Here

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08.07.2019 - New research article on TRP channels expression signature in tumor-derived endothelial cells. 

Bernardini M, Brossa A, Chinigo G, Grolez GP, Trimaglio G, Allart L, Hulot A, Marot G, Genova T, Joshi A, Mattot V, Fromont G, Munaron L, Bussolati B, Prevarskaya N, Fiorio Pla A, Gkika D.
Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis.
Cancers (Basel). 2019 Jul 8;11(7) 
Here

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05.06.2019 - New review article on monoclonal antibodies targeting ion channels.  

Haustrate A, Hantute-Ghesquier A, Prevarskaya N, Lehen'kyi V.
Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential.
Front. Pharmacol. 2019 June 
Here

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22.04.2019 - New article on the use of nanotechnologies to target TRPM8.  

Grolez GP, Hammadi M, Barras A, Gordienko D, Slomianny C, Völkel P, Angrand PO, Pinault M, Guimaraes C, Potier-Cartereau M, Prevarskaya N, Boukherroub R, Gkika D.
Encapsulation of a TRPM8 Agonist, WS12, in Lipid Nanocapsules Potentiates PC3 Prostate Cancer Cell Migration Inhibition through Channel Activation.
Sci Rep. 2019 May 28;9(1):7926. doi: 10.1038/s41598-019-44452-4.
PubMed

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22.04.2019 - New review article on the TRPV6 regulation and targeting in cancer.  

Haustrate A, Hantute-Ghesquier A, Prevarskaya N, Lehen'kyi V.
TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer.
Cell Calcium. 2019 Jun;80:117-124. doi: 10.1016/j.ceca.2019.04.006.
PubMed

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10.04.2019 - New article on the evolution of the human cold/menthol receptor, TRPM8.  

Blanquart S, Borowiec AS, Delcourt P, Figeac M, Emerling CA, Meseguer AS, Roudbaraki M, Prevarskaya N, Bidaux G.
Evolution of the human cold/menthol receptor, TRPM8.
Mol Phylogenet Evol. 2019 Jul;136:104-118. doi: 10.1016/j.ympev.2019.04.011.
PubMed

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11.09.2018 - Protocols to quantify CRAC components expression as well to study endogenous STIM/ORAI and protein partners. 

Dubois C, Prevarskaya N.
Western Blotting and Co-immunoprecipitation of Endogenous STIM/ORAI and Protein Partners.
Methods Mol Biol. 2018;1843:107-113. doi: 10.1007/978-1-4939-8704-7_9.
PubMed

Dubois C, Lehenkyi V, Prevarskaya N.
CRAC Channel Components Quantitative Expression (In Tissues and Cell Lines) Using qPCR.
Methods Mol Biol. 2018;1843:95-106. doi: 10.1007/978-1-4939-8704-7_8.
PubMed

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21.06.2018 - New article demonstrating that TRPV1 variants may confer susceptibility to malignant hyperthermia.

Vanden Abeele F, Lotteau S, Ducreux S, Dubois C, Monnier N, Hanna A, Gkika D, Romestaing C, Noyer L, Flourakis M, Tessier N, Al-Mawla R, Chouabe C, Lefai E, Lunardi J, Hamilton S, Fauré J, Van Coppenolle F, Prevarskaya N.
TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia.
Genet Med. 2018 Jun 21. doi: 10.1038/s41436-018-0066-9.
PubMed

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20.06.2018 - New review article on the role of TRPM8 channel in prostate carcinogenesis.

Noyer L, Grolez GP, Prevarskaya N, Gkika D, Lemonnier L.
TRPM8 and prostate: a cold case?
Pflugers Arch. 2018 Jun 20. doi: 10.1007/s00424-018-2169-1.
PubMed

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07.06.2018 - New review article on the role of TRPM channels in cancer.

Hantute-Ghesquier A, Haustrate A, Prevarskaya N, Lehen'kyi V.
TRPM Family Channels in Cancer.
Pharmaceuticals (Basel). 2018 Jun 7;11(2). pii: E58. doi: 10.3390/ph11020058.
PubMed

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23.04.2018 - New article on the role of TRPM8 isoform in the regulation of mitochondrial and ER calcium.

Bidaux G, Gordienko D, Shapovalov G, Farfariello V, Borowiec AS, Iamshanova O, Lemonnier L, Gueguinou M, Guibon R, Fromont G, Paillard M, Gouriou Y, Chouabe C, Dewailly E, Gkika D, López-Alvarado P, Carlos Menéndez J, Héliot L, Slomianny C, Prevarskaya N.
4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca2+ transfer.
Biochim Biophys Acta. 2018 Apr 17. doi: 10.1016/j.bbamcr.2018.04.007.
PubMed

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02.04.2018 - New review article on the role of ion channels in cancer.

Prevarskaya N, Skryma R, Shuba Y.
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Physiol Rev. 2018 Apr 1;98(2):559-621. doi: 10.1152/physrev.00044.2016.
PubMed

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21.11.2017 - New article revealing the antitumor activity of an antimalarial ferroquine.

Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon RA, Slomianny C, Lemière S, Delcourt P, Dewailly E, Skryma R, Biot C, Prevarskaya N.
Ferroquine, the next generation antimalarial drug, has antitumor activity.
Sci Rep. 2017 Nov 21;7(1):15896. doi: 10.1038/s41598-017-16154-2.
PubMed

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30.10.2017 - New article on the novel universal approach to study intracellular ion channels.

Shapovalov G, Ritaine A, Bidaux G, Slomianny C, Borowiec AS, Gordienko D, Bultynck G, Skryma R, Prevarskaya N.
Organelle membrane derived patches: reshaping classical methods for new targets.
Sci Rep. 2017 Oct 26;7(1):14082. doi: 10.1038/s41598-017-13968-y.
PubMed

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16.10.2017 - New review article on the role of ion channels in the regulation of autophagy.

Kondratskyi A, Kondratska K, Skryma R, Klionsky DJ, Prevarskaya N.
Ion channels in the regulation of autophagy.
Autophagy. 2017 Oct 5:0. doi: 10.1080/15548627.2017.1384887.
PubMed

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15.09.2017 - New review article on the role of IP3R-Mediated Ca2+ Release in Migration and Invasion.

Ritaine A, Shapovalov G, Prevarskaya N.
Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion.
Adv Exp Med Biol. 2017;993:623-637. doi: 10.1007/978-3-319-57732-6_31.
PubMed

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15.07.2017 - New review article on the role of TRP channels and calcium in cell death and survival.

Fliniaux I, Germain E, Farfariello V, Prevarskaya N.
TRPs and Ca2+ in cell death and survival.
Cell Calcium. 2017 Jul 15. pii: S0143-4160(17)30081-7. doi: 10.1016/j.ceca.2017.07.002.
PubMed

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31.05.2017 - New publication showing that a TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1.

Genova T, Grolez GP, Camillo C, Bernardini M, Bokhobza A, Richard E, Scianna M, Lemonnier L, Valdembri D, Munaron L, Philips MR, Mattot V, Serini G, Prevarskaya N, Gkika D, Pla AF.
TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1.
J Cell Biol. 2017 Jul 3;216(7):2107-2130. doi: 10.1083/jcb.201506024. Epub 2017 May 26.
PubMed

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10.04.2017 - New review article on calcium signalling in cancer.

Monteith GR, Prevarskaya N, Roberts-Thomson SJ.
The calcium-cancer signalling nexus.
Nat Rev Cancer. 2017 Apr 7. doi: 10.1038/nrc.2017.18.
PubMed

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22.03.2017 - New review article on molecular mechanisms of tumor invasion.

Iamshanova O, Fiorio Pla A, Prevarskaya N.
Molecular mechanisms of tumor invasion: regulation by calcium signals.
J Physiol. 2017 Mar 17. doi: 10.1113/JP272844.
PubMed

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14.03.2017 - New publication on TRPA1 in prostate cancer associated fibroblasts.

Vancauwenberghe E, Noyer L, Derouiche S, Lemonnier L, Gosset P, Sadofsky LR, Mariot P, Warnier M, Bokhobza A, Slomianny C, Mauroy B, Bonnal JL, Dewailly E, Delcourt P, Allart L, Prevarskaya N, Roudbaraki M.
Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).
Mol Carcinog. 2017 Mar 9. doi: 10.1002/mc.22642.
PubMed

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11.02.2017 - International Day of Women and Girls in Science. Read more... 

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17.01.2017 - New publication showing that TRPA1 could mediate the effects of environmental factors on tumor microenvironment interactions and prostate cancer progression. 

Derouiche S, Mariot P, Warnier M, Vancauwenberghe E, Bidaux G, Gosset P, Mauroy B, Bonnal JL, Slomianny C, Delcourt P, Dewailly E, Prevarskaya N, Roudbaraki M.
Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells.
Cancer Prev Res (Phila). 2017 Mar;10(3):177-187.
PubMed

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21.11.2016 - First Test Phycell Chess Championship. Congratulations to Pascal and Mirto! Pascal won the first prize and Mirto won the secon prize of the First Test Phycell Chess Championship.

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22.09.2016 - New publication on sodium imaging in prostate cancer cell lines.

Iamshanova O, Mariot P, Lehen'kyi V, Prevarskaya N.
Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines.
Eur Biophys J. 2016 Oct;45(7):765-777.
PubMed